{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T20:50:27Z","timestamp":1780692627149,"version":"3.54.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T00:00:00Z","timestamp":1476316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"ESLHO::EuroClonality, and an OVC Pet Trust Research Grant with the University of Guelph","award":["051699"],"award-info":[{"award-number":["051699"]}]},{"name":"ESLHO::EuroClonality, and an OVC Pet Trust Research Grant with the University of Guelph","award":["MEYS-NPS I-LO1413"],"award-info":[{"award-number":["MEYS-NPS I-LO1413"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>The study of immunoglobulins and T cell receptors using next-generation sequencing has finally allowed exploring immune repertoires and responses in their immense variability and complexity. Unsurprisingly, their analysis and interpretation is a highly convoluted task.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We thus implemented ARResT\/Interrogate, a web-based, interactive application. It can organize and filter large amounts of immunogenetic data by numerous criteria, calculate several relevant statistics, and present results in the form of multiple interconnected visualizations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>ARResT\/Interrogate is implemented primarily in R, and is freely available at http:\/\/bat.infspire.org\/arrest\/interrogate\/<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw634","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T07:05:50Z","timestamp":1475564750000},"page":"435-437","source":"Crossref","is-referenced-by-count":94,"title":["ARResT\/Interrogate: an interactive immunoprofiler for IG\/TR NGS data"],"prefix":"10.1093","volume":"33","author":[{"given":"Vojtech","family":"Bystry","sequence":"first","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology, Masaryk University, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Reigl","sequence":"additional","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology, Masaryk University, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Krejci","sequence":"additional","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology, Masaryk University, Brno, Czech Republic"},{"name":"RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Demko","sequence":"additional","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology, Masaryk University, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbora","family":"Hanakova","sequence":"additional","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology, Masaryk University, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Grioni","sequence":"additional","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology, Masaryk University, Brno, Czech Republic"},{"name":"Centro Ricerca Tettamanti, Clinica Pediatrica, Universit\u00e0 di Milano-Bicocca, Ospedale San Gerardo\/Fondazione MBBM, Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Knecht","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Schlitt","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dreger","sequence":"additional","affiliation":[{"name":"Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopold","family":"Sellner","sequence":"additional","affiliation":[{"name":"Department of Medicine V, University Hospital Heidelberg, Heidelberg, 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Pott","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton W","family":"Langerak","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia J. T.A","family":"Groenen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Davi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hopital Piti\u00e9-Salp\u00eatri\u00e8re and Pierre et Marie Curie University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Darzentas","sequence":"additional","affiliation":[{"name":"CEITEC \u2013 Central European Institute of Technology, Masaryk University, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"EuroClonality-NGS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,10,13]]},"reference":[{"key":"2023020204403037100_btw634-B1","first-page":"26.","article-title":"IMGT\/HighV-QUEST: the IMGT\u00ae web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis from NGS high throughput and deep sequencing","volume":"8","author":"Alamyar","year":"2012","journal-title":"Immunome Res"},{"key":"2023020204403037100_btw634-B2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2567.2011.03527.x","article-title":"Rep-Seq: uncovering the immunological repertoire through next-generation sequencing","volume":"135","author":"Benichou","year":"2012","journal-title":"Immunology"},{"key":"2023020204403037100_btw634-B3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1186\/1471-2164-15-409","article-title":"Fast multiclonal clusterization of V(D)J recombinations from high-throughput sequencing","volume":"15","author":"Giraud","year":"2014","journal-title":"BMC Genomics"},{"key":"2023020204403037100_btw634-B4","doi-asserted-by":"crossref","first-page":"D413","DOI":"10.1093\/nar\/gku1056","article-title":"IMGT\u00ae, the international ImMunoGeneTics information system\u00ae 25 years on","volume":"43","author":"Lefranc","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2023020204403037100_btw634-B5","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1038\/ncomms3333","article-title":"IMGT\/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling","volume":"4","author":"Li","year":"2013","journal-title":"Nat. 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