{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:14:28Z","timestamp":1772752468614,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T00:00:00Z","timestamp":1476403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30ES005022"],"award-info":[{"award-number":["P30ES005022"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15ES023148"],"award-info":[{"award-number":["R15ES023148"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"publisher","award":["HHSN273201500010C"],"award-info":[{"award-number":["HHSN273201500010C"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>We have developed a public Chemical In vitro\u2013In vivo Profiling (CIIPro) portal, which can automatically extract in vitro biological data from public resources (i.e. PubChem) for user-supplied compounds. For compounds with in vivo target activity data (e.g. animal toxicity testing results), the integrated cheminformatics algorithm will optimize the extracted biological data using in vitro\u2013in vivo correlations. The resulting in vitro biological data for target compounds can be used for read-across risk assessment of target compounds. Additionally, the CIIPro portal can identify the most similar compounds based on their optimized bioprofiles. The CIIPro portal provides new powerful assessment capabilities to the scientific community and can be easily integrated with other cheminformatics tools.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>ciipro.rutgers.edu.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw640","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T14:19:40Z","timestamp":1476195580000},"page":"464-466","source":"Crossref","is-referenced-by-count":29,"title":["CIIPro: a new read-across portal to fill data gaps using public large-scale chemical and biological data"],"prefix":"10.1093","volume":"33","author":[{"given":"Daniel P","family":"Russo","sequence":"first","affiliation":[{"name":"The Rutgers Center for Computational and Integrative Biology, Camden, NJ, USA"}]},{"given":"Marlene T","family":"Kim","sequence":"additional","affiliation":[{"name":"The Rutgers Center for Computational and Integrative Biology, Camden, NJ, USA"},{"name":"Department of Chemistry, Rutgers University, Camden, NJ, USA"}]},{"given":"Wenyi","family":"Wang","sequence":"additional","affiliation":[{"name":"The Rutgers Center for Computational and Integrative Biology, Camden, NJ, USA"}]},{"given":"Daniel","family":"Pinolini","sequence":"additional","affiliation":[{"name":"The Rutgers Center for Computational and Integrative Biology, Camden, NJ, USA"}]},{"given":"Sunil","family":"Shende","sequence":"additional","affiliation":[{"name":"The Rutgers Center for Computational and Integrative Biology, Camden, NJ, USA"},{"name":"Department of Computer Science, Rutgers University, Camden, NJ, USA"}]},{"given":"Judy","family":"Strickland","sequence":"additional","affiliation":[{"name":"ILS, Research Triangle Park, NC, USA"}]},{"given":"Thomas","family":"Hartung","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA"},{"name":"University of Konstanz, CAAT-Europe, Konstanz, Germany"}]},{"given":"Hao","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Rutgers Center for Computational and Integrative Biology, Camden, NJ, USA"},{"name":"Department of Chemistry, Rutgers University, Camden, NJ, USA"}]}],"member":"286","published-online":{"date-parts":[[2016,10,14]]},"reference":[{"key":"2023020204405416400_btw640-B1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.14573\/altex.1601251","article-title":"Toward Good Read-Across Practice (GRAP) guidance","volume":"33","author":"Ball","year":"2016","journal-title":"Altex"},{"key":"2023020204405416400_btw640-B2","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1007\/s11095-013-1222-1","article-title":"Critical evaluation of human oral bioavailability for pharmaceutical drugs by using various cheminformatics approaches","volume":"31","author":"Kim","year":"2014","journal-title":"Pharm. 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