{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:34:41Z","timestamp":1772138081482,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T00:00:00Z","timestamp":1476403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"NIH","award":["3P50MH094267-04S1"],"award-info":[{"award-number":["3P50MH094267-04S1"]}]},{"name":"NIH","award":["1R01MH101820-02S1"],"award-info":[{"award-number":["1R01MH101820-02S1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Over the last decade, genome-wide association studies (GWAS) have generated vast amounts of analysis results, requiring development of novel tools for data visualization. Quantile\u2013quantile (QQ) plots and Manhattan plots are classical tools which have been utilized to visually summarize GWAS results and identify genetic variants significantly associated with traits of interest. However, static visualizations are limiting in the information that can be shown. Here, we present Assocplots, a Python package for viewing and exploring GWAS results not only using classic static Manhattan and QQ plots, but also through a dynamic extension which allows to interactively visualize the relationships between GWAS results from multiple cohorts or studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and Implementation<\/jats:title>\n                    <jats:p>The Assocplots package is open source and distributed under the MIT license via GitHub (https:\/\/github.com\/khramts\/assocplots) along with examples, documentation and installation instructions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw641","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T15:05:32Z","timestamp":1476198332000},"page":"432-434","source":"Crossref","is-referenced-by-count":16,"title":["Assocplots: a Python package for static and interactive visualization of multiple-group GWAS results"],"prefix":"10.1093","volume":"33","author":[{"given":"Ekaterina A","family":"Khramtsova","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL, USA"},{"name":"Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, USA"}]},{"given":"Barbara E","family":"Stranger","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Genetic Medicine, The University of Chicago, Chicago, IL, USA"},{"name":"Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, USA"},{"name":"Center for Data Intensive Science, The University of Chicago, Chicago, IL, USA"}]}],"member":"286","published-online":{"date-parts":[[2016,10,14]]},"reference":[{"key":"2023020204402860500_btw641-B1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1534\/genetics.114.172742","article-title":"R\/qtlcharts: interactive graphics for quantitative trait locus mapping","volume":"199","author":"Broman","year":"2015","journal-title":"Genetics"},{"key":"2023020204402860500_btw641-B2","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies","volume":"55","author":"Devlin","year":"1999","journal-title":"Biometrics"},{"key":"2023020204402860500_btw641-B3","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1101\/gr.071571.107","article-title":"WGAViewer: software for genomic annotation of whole genome association studies","volume":"18","author":"Ge","year":"2008","journal-title":"Genome Res"},{"key":"2023020204402860500_btw641-B4","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1093\/bioinformatics\/btv402","article-title":"LDlink a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants","volume":"31","author":"Machiela","year":"2015","journal-title":"Bioinformatics"},{"key":"2023020204402860500_btw641-B5","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/bioinformatics\/btq419","article-title":"LocusZoom: regional visualization of genome-wide association scan results","volume":"26","author":"Pruim","year":"2010","journal-title":"Bioinformatics"},{"key":"2023020204402860500_btw641-B6","doi-asserted-by":"crossref","first-page":"e1003500.","DOI":"10.1371\/journal.pgen.1003500","article-title":"Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits","volume":"9","author":"Randall","year":"2013","journal-title":"PLoS Genet"},{"key":"2023020204402860500_btw641-B7","article-title":"qqman: an R package for visualizing GWAS results using Q-Q and Manhattan plots","author":"Turner","year":"2014","journal-title":"bioRxiv"},{"key":"2023020204402860500_btw641-B8","doi-asserted-by":"crossref","DOI":"10.7717\/peerj-cs.3","article-title":"Zbrowse: an interactive GWAS results browser","author":"Zeigler","year":"2015","journal-title":"PeerJ Comput. Sci"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/33\/3\/432\/49037233\/bioinformatics_33_3_432.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/33\/3\/432\/49037233\/bioinformatics_33_3_432.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T23:40:40Z","timestamp":1675294840000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/33\/3\/432\/2593901"}},"subtitle":[],"editor":[{"given":"Alfonso","family":"Valencia","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2016,10,14]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btw641","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/062737","asserted-by":"object"}]},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,2,1]]},"published":{"date-parts":[[2016,10,14]]}}}