{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:18:06Z","timestamp":1783685886046,"version":"3.55.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Large high-throughput screening (HTS) efforts are widely used in drug development and chemical toxicity screening. Wide use and integration of these data can benefit from an efficient, transparent and reproducible data pipeline. Summary: The tcpl R package and its associated MySQL database provide a generalized platform for efficiently storing, normalizing and dose-response modeling of large high-throughput and high-content chemical screening data. The novel dose-response modeling algorithm has been tested against millions of diverse dose-response series, and robustly fits data with outliers and cytotoxicity-related signal loss.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>tcpl is freely available on the Comprehensive R Archive Network under the GPL-2 license.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw680","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T19:06:25Z","timestamp":1477422385000},"page":"618-620","source":"Crossref","is-referenced-by-count":210,"title":["tcpl: the ToxCast pipeline for high-throughput screening data"],"prefix":"10.1093","volume":"33","author":[{"given":"Dayne L","family":"Filer","sequence":"first","affiliation":[{"name":"Oak Ridge Institute for Science Education Fellow at National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth","family":"Kothiya","sequence":"additional","affiliation":[{"name":"Oak Ridge Institute for Science Education Fellow at National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Woodrow","family":"Setzer","sequence":"additional","affiliation":[{"name":"National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S","family":"Judson","sequence":"additional","affiliation":[{"name":"National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T","family":"Martin","sequence":"additional","affiliation":[{"name":"National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,11,22]]},"reference":[{"key":"2023020204430172800_btw680-B1","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1126\/science.1105511","article-title":"NIH molecular libraries initiative","volume":"306","author":"Austin","year":"2004","journal-title":"Science"},{"key":"2023020204430172800_btw680-B2","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1126\/science.1154619","article-title":"Transforming environmental health protection","volume":"319","author":"Collins","year":"2008","journal-title":"Science"},{"key":"2023020204430172800_btw680-B3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfl103","article-title":"The ToxCast program for prioritizing toxicity testing of environmental chemicals","volume":"95","author":"Dix","year":"2007","journal-title":"Toxicol. 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