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It is a network-based approach designed to navigate through topological relationships between genes (signaling- or metabolic-genes) and metabolites, representing a powerful tool to investigate the genetic landscape of metabolic phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and Implementation<\/jats:title>\n                    <jats:p>MetaboSignal is available from Bioconductor: https:\/\/bioconductor.org\/packages\/MetaboSignal\/<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw697","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T16:06:46Z","timestamp":1478189206000},"page":"773-775","source":"Crossref","is-referenced-by-count":24,"title":["MetaboSignal: a network-based approach for topological analysis of metabotype regulation\n                    <i>via<\/i>\n                    metabolic and signaling pathways"],"prefix":"10.1093","volume":"33","author":[{"given":"Andrea","family":"Rodriguez-Martinez","sequence":"first","affiliation":[{"name":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK"}]},{"given":"Rafael","family":"Ayala","sequence":"additional","affiliation":[{"name":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK"}]},{"given":"Joram M","family":"Posma","sequence":"additional","affiliation":[{"name":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK"}]},{"given":"Ana L","family":"Neves","sequence":"additional","affiliation":[{"name":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK"}]},{"given":"Dominique","family":"Gauguier","sequence":"additional","affiliation":[{"name":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK"},{"name":"Sorbonne Universities, University Pierre & Marie Curie, University Paris Descartes, Sorbonne Paris Cit\u00e9, INSERMUMR_S, Cordeliers Research Centre, Paris, France"}]},{"given":"Jeremy K","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK"}]},{"given":"Marc-Emmanuel","family":"Dumas","sequence":"additional","affiliation":[{"name":"Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK"}]}],"member":"286","published-online":{"date-parts":[[2016,12,5]]},"reference":[{"key":"2023020204510965700_btw697-B1","article-title":"igraph package","author":"Csardi","year":"2015","journal-title":"The Comprehensive R Archive Network, v1.0.1"},{"key":"2023020204510965700_btw697-B2","doi-asserted-by":"crossref","first-page":"W132","DOI":"10.1093\/nar\/gkq312","article-title":"Metexplore: a web server to link metabolomic experiments and genome-scale metabolic networks","volume":"38","author":"Cottret","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"2023020204510965700_btw697-B3","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1101\/gr.116764.110","article-title":"A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model","volume":"21","author":"Davidovic","year":"2011","journal-title":"Genome Res"},{"key":"2023020204510965700_btw697-B4","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1039\/c2mb25167a","article-title":"Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypes","volume":"8","author":"Dumas","year":"2012","journal-title":"Mol. 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