{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T05:29:21Z","timestamp":1675315761935},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T00:00:00Z","timestamp":1481328000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>We have developed geneAttribution, an R package that assigns candidate causal gene(s) to a risk variant identified by a genetic association study such as a GWAS. The method combines user-supplied functional annotation such as expression quantitative trait loci (eQTL) or Hi-C genome conformation data and reports the most likely candidate genes. In the absence of annotation data, geneAttribution relies on the distances between the genes and the input variant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>The package is freely available from http:\/\/www.bioconductor.org\/. A quick-start vignette is included with the package.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw698","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T20:05:29Z","timestamp":1478117129000},"page":"599-600","source":"Crossref","is-referenced-by-count":0,"title":["geneAttribution: trait agnostic identification of candidate genes associated with noncoding variation"],"prefix":"10.1093","volume":"33","author":[{"given":"Arthur","family":"Wuster","sequence":"first","affiliation":[{"name":"Department of Human Genetics, Genentech Inc, South San Francisco, CA, USA"},{"name":"Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, CA, USA"}]},{"given":"Diana","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Genentech Inc, South San Francisco, CA, USA"}]},{"given":"Timothy W","family":"Behrens","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Genentech Inc, South San Francisco, CA, USA"}]},{"given":"Tushar R","family":"Bhangale","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, Genentech Inc, South San Francisco, CA, USA"},{"name":"Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, CA, USA"}]}],"member":"286","published-online":{"date-parts":[[2016,11,29]]},"reference":[{"key":"2023020204423515600_btw698-B1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans","volume":"348","author":"GTEx Consortium","year":"2015","journal-title":"Science"},{"key":"2023020204423515600_btw698-B2","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nature04226","article-title":"A haplotype map of the human genome","volume":"437","author":"International HapMap Consortium","year":"2005","journal-title":"Nature"},{"key":"2023020204423515600_btw698-B3","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1222794","article-title":"Systematic localization of common disease-associated variation in regulatory DNA","volume":"337","author":"Maurano","year":"2012","journal-title":"Science"},{"key":"2023020204423515600_btw698-B4","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/ng.3286","article-title":"Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C","volume":"47","author":"Mifsud","year":"2015","journal-title":"Nat Genet"},{"key":"2023020204423515600_btw698-B5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature12873","article-title":"Genetics of rheumatoid arthritis contributes to biology and drug discovery","volume":"506","author":"Okada","year":"2013","journal-title":"Nature"},{"key":"2023020204423515600_btw698-B6","doi-asserted-by":"crossref","first-page":"D1001","DOI":"10.1093\/nar\/gkt1229","article-title":"The NHGRI GWAS Catalog, a curated resource of SNP-trait associations","volume":"42","author":"Welter","year":"2014","journal-title":"Nucleic Acids Res"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/33\/4\/599\/49037788\/bioinformatics_33_4_599.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/33\/4\/599\/49037788\/bioinformatics_33_4_599.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T04:42:47Z","timestamp":1675312967000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/33\/4\/599\/2666347"}},"subtitle":[],"editor":[{"given":"Oliver","family":"Stegle","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2016,11,29]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,2,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btw698","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,2,15]]},"published":{"date-parts":[[2016,11,29]]}}}