{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T08:54:08Z","timestamp":1775984048071,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T00:00:00Z","timestamp":1481587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Dynamics of cellular processes are often studied using mechanistic mathematical models. These models possess unknown parameters which are generally estimated from experimental data assuming normally distributed measurement noise. Outlier corruption of datasets often cannot be avoided. These outliers may distort the parameter estimates, resulting in incorrect model predictions. Robust parameter estimation methods are required which provide reliable parameter estimates in the presence of outliers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In this manuscript, we propose and evaluate methods for estimating the parameters of ordinary differential equation models from outlier-corrupted data. As alternatives to the normal distribution as noise distribution, we consider the Laplace, the Huber, the Cauchy and the Student\u2019s t distribution. We assess accuracy, robustness and computational efficiency of estimators using these different distribution assumptions. To this end, we consider artificial data of a conversion process, as well as published experimental data for Epo-induced JAK\/STAT signaling. We study how well the methods can compensate and discover artificially introduced outliers. Our evaluation reveals that using alternative distributions improves the robustness of parameter estimates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>The MATLAB implementation of the likelihood functions using the distribution assumptions is available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary material are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw703","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T12:07:31Z","timestamp":1478261251000},"page":"718-725","source":"Crossref","is-referenced-by-count":44,"title":["Robust parameter estimation for dynamical systems from outlier-corrupted data"],"prefix":"10.1093","volume":"33","author":[{"given":"Corinna","family":"Maier","sequence":"first","affiliation":[{"name":"Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany"},{"name":"Technische Universit\u00e4t M\u00fcnchen, Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Garching, Germany"}]},{"given":"Carolin","family":"Loos","sequence":"additional","affiliation":[{"name":"Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany"},{"name":"Technische Universit\u00e4t M\u00fcnchen, Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Garching, Germany"}]},{"given":"Jan","family":"Hasenauer","sequence":"additional","affiliation":[{"name":"Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Institute of Computational Biology, Neuherberg, Germany"},{"name":"Technische Universit\u00e4t M\u00fcnchen, Center for Mathematics, Chair of Mathematical Modeling of Biological Systems, Garching, Germany"}]}],"member":"286","published-online":{"date-parts":[[2016,12,13]]},"reference":[{"key":"2023020204501866600_btw703-B1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cell.2005.04.020","article-title":"Systems biology: its practice and challenges","volume":"121","author":"Aderem","year":"2005","journal-title":"Cell"},{"key":"2023020204501866600_btw703-B2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-3-319-14142-8_8","volume-title":"Data Mining","author":"Aggarwal","year":"2015"},{"key":"2023020204501866600_btw703-B3","first-page":"267","volume-title":"2nd International Symposium on Information Theory, Tsahkadsor, Armenian SSR","author":"Akaike","year":"1973"},{"key":"2023020204501866600_btw703-B4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/0-387-25465-X_7","volume-title":"Data Mining and Knowledge Discovery Handbook","author":"Ben-Gal","year":"2005"},{"key":"2023020204501866600_btw703-B5","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/j.1541-0420.2011.01577.x","article-title":"Robust estimation for ordinary differential equation models","volume":"67","author":"Cao","year":"2011","journal-title":"Biometrics"},{"key":"2023020204501866600_btw703-B6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ab.2013.07.022","article-title":"Absolute quantitation of endogenous proteins with precision and accuracy using a capillary western system","volume":"442","author":"Chen","year":"2013","journal-title":"Anal. 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