{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:34:15Z","timestamp":1774989255261,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T00:00:00Z","timestamp":1482364800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-MH105527"],"award-info":[{"award-number":["R01-MH105527"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Spatiotemporal transcriptomic profiling has provided valuable insight into the patterning of gene expression throughout the human brain from early fetal development to adulthood. When combined with prior knowledge of a disease\u2019s age at onset and region-specificity, these expression profiles have provided the necessary context to both strengthen putative gene\u2013disease associations and infer new associations. While a wealth of spatiotemporal expression data exists, there are currently no tools available to visualize this data within the anatomical context of the brain, thus limiting the intuitive interpretation of many such findings. We present cerebroViz, an R package to map spatiotemporal brain data to vector graphic diagrams of the human brain. Our tool allows rapid generation of publication-quality figures that highlight spatiotemporal trends in the input data, while striking a balance between usability and customization. cerebroViz is generalizable to any data quantifiable at a brain-regional resolution and currently supports visualization of up to thirty regions of the brain found in databases such as BrainSpan, GTEx and Roadmap Epigenomics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>cerebroViz is freely available through GitHub (https:\/\/github.com\/ethanbahl\/cerebroViz). The tutorial is available at http:\/\/ethanbahl.github.io\/cerebroViz\/<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw726","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T20:05:49Z","timestamp":1479326749000},"page":"762-763","source":"Crossref","is-referenced-by-count":38,"title":["cerebroViz: an R package for anatomical visualization of spatiotemporal brain data"],"prefix":"10.1093","volume":"33","author":[{"given":"Ethan","family":"Bahl","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA"}]},{"given":"Tanner","family":"Koomar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA"}]},{"given":"Jacob J","family":"Michaelson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA"}]}],"member":"286","published-online":{"date-parts":[[2016,12,15]]},"reference":[{"key":"2023020204502060300_btw726-B1","article-title":"BrainSpan: Atlas of the Developing Human Brain [Internet]. Funded by ARRA Awards 1RC2MH089921-01, 1RC2MH090047-01, and 1RC2MH089929-01. \u00a9 2011. http:\/\/developinghumanbrain.org","author":"BrainSpan","year":"2014"},{"key":"2023020204502060300_btw726-B2","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.neuron.2010.08.040","article-title":"Structural MRI of pediatric brain development: what have we learned and where are we going?","volume":"67","author":"Giedd","year":"2010","journal-title":"Neuron"},{"key":"2023020204502060300_btw726-B3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","author":"GTEx Consortium","year":"2013","journal-title":"Nat. Genet"},{"key":"2023020204502060300_btw726-B4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature10523","article-title":"Spatio-temporal transcriptome of the human brain","volume":"478","author":"Kang","year":"2011","journal-title":"Nature"},{"key":"2023020204502060300_btw726-B5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"2023020204502060300_btw726-B7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ajhg.2016.02.004","article-title":"Disruption of POGZ is associated with intellectual disability and autism spectrum disorders","volume":"98","author":"Stessman","year":"2016","journal-title":"Am. J. Hum. Genet"},{"key":"2023020204502060300_btw726-B8","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/WCO.0000000000000069","article-title":"The developmental transcriptome of the human brain: implications for neurodevelopmental disorders","volume":"27","author":"Tebbenkamp","year":"2014","journal-title":"Curr. Opin. Neurol"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/33\/5\/762\/49037756\/bioinformatics_33_5_762.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/33\/5\/762\/49037756\/bioinformatics_33_5_762.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T04:51:36Z","timestamp":1675313496000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/33\/5\/762\/2627423"}},"subtitle":[],"editor":[{"given":"Bonnie","family":"Berger","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2016,12,15]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btw726","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,3,1]]},"published":{"date-parts":[[2016,12,15]]}}}