{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:04:41Z","timestamp":1772755481785,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2016,11,26]],"date-time":"2016-11-26T00:00:00Z","timestamp":1480118400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Biotempo","award":["ANR-10-BLANC-0218"],"award-info":[{"award-number":["ANR-10-BLANC-0218"]}]},{"name":"TGFSysBio","award":["2014\u20132018"],"award-info":[{"award-number":["2014\u20132018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>We introduce the caspo toolbox, a python package implementing a workflow for reasoning on logical networks families. Our software allows researchers to (i) learn a family of logical networks derived from a given topology and explaining the experimental response to various perturbations; (ii) classify all logical networks in a given family by their input-output behaviors; (iii) predict the response of the system to every possible perturbation based on the ensemble of predictions; (iv) design new experimental perturbations to discriminate among a family of logical networks; and (v) control a family of logical networks by finding all interventions strategies forcing a set of targets into a desired steady state.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>caspo is open-source software distributed under the GPLv3 license. Source code is publicly hosted at http:\/\/github.com\/bioasp\/caspo.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw738","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T20:05:56Z","timestamp":1479585956000},"page":"947-950","source":"Crossref","is-referenced-by-count":18,"title":["caspo: a toolbox for automated reasoning on the response of logical signaling networks families"],"prefix":"10.1093","volume":"33","author":[{"given":"Santiago","family":"Videla","sequence":"first","affiliation":[{"name":"LBSI, Fundaci\u00f3n Instituto Leloir (IIBBA-CONICET), Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Saez-Rodriguez","sequence":"additional","affiliation":[{"name":"RWTH Aachen University, Faculty of Medicine, Joint Research Centre for Computational Biomedicine, Aachen, Germany"},{"name":"European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carito","family":"Guziolowski","sequence":"additional","affiliation":[{"name":"IRCCyN UMR CNRS 6597, \u00c9cole Centrale de Nantes, Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Siegel","sequence":"additional","affiliation":[{"name":"CNRS, UMR 6074-IRISA, Rennes, France"},{"name":"Dyliss project, INRIA, Campus de Beaulieu, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"2023020204513948700_btw738-B1","doi-asserted-by":"crossref","first-page":"94.","DOI":"10.3389\/fgene.2016.00094","article-title":"Logical modeling and dynamical analysis of cellular networks","volume":"7","author":"Abou-Jaoud\u00e9","year":"2016","journal-title":"Front. 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