{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T01:55:32Z","timestamp":1761789332606},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"Canadian Institutes of Health Research (CIHR Team Grant: HIV Cure Research\u2014The Canadian HIV Cure Research Enterprise; CanCure","award":["HIG-133050"],"award-info":[{"award-number":["HIG-133050"]}]},{"name":"Bill and Melinda Gates","award":["OPP1110049"],"award-info":[{"award-number":["OPP1110049"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Phylogenetic trees encode the evolutionary distances between species or populations. With sufficient information, these evolutionary distances can be rescaled over time to provide estimates of the dates of the most recent ancestors of the species. Here we present the R program node.dating, divergence-time analysis software, which uses a maximum-likelihood method to estimate the dates of the internal nodes of a phylogenetic tree.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>node.dating is available as a part of the R v3.30 package ape v4.0 (cran.r-project.org). node.dating is also available in the GitHub repository: https:\/\/github.com\/brj1\/node.dating, along with supplementary software and tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw744","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T20:17:58Z","timestamp":1479759478000},"page":"932-934","source":"Crossref","is-referenced-by-count":18,"title":["node.dating: dating ancestors in phylogenetic trees in R"],"prefix":"10.1093","volume":"33","author":[{"given":"Bradley R","family":"Jones","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada"},{"name":"BC Centre for Excellence in HIV\/AIDS, Vancouver, Canada"}]},{"given":"Art F Y","family":"Poon","sequence":"additional","affiliation":[{"name":"BC Centre for Excellence in HIV\/AIDS, Vancouver, Canada"},{"name":"Department of Medicine, University of British Columbia, British Columbia, Canada"},{"name":"Department of Pathology and Laboratory Medicine, Western University, London, Canada"}]}],"member":"286","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"2023020204515117600_btw744-B1","doi-asserted-by":"crossref","first-page":"214.","DOI":"10.1186\/1471-2148-7-214","article-title":"BEAST: Bayesian evolutionary analysis by sampling trees","volume":"7","author":"Drummond","year":"2007","journal-title":"BMC Evol. Biol"},{"key":"2023020204515117600_btw744-B2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/BF01734359","article-title":"Evolutionary trees from DNA sequences: a maximum likelihood approach","volume":"17","author":"Felsenstein","year":"1981","journal-title":"J. Mol. Evol"},{"key":"2023020204515117600_btw744-B3","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/molbev\/msw026","article-title":"Advances in time estimation methods for molecular data","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol"},{"key":"2023020204515117600_btw744-B4","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1189\/jlb.0306144","article-title":"Continued evolution of HIV-1 circulating in blood monocytes with antiretroviral therapy: genetic analysis of HIV-1 in monocytes and CD4+ T cells of patients with discontinued therapy","volume":"80","author":"Llewellyn","year":"2006","journal-title":"J. Leukoc. 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