{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T18:07:50Z","timestamp":1694714870769},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T00:00:00Z","timestamp":1484956800000},"content-version":"vor","delay-in-days":31,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"Human Frontier in Science Program Long-Term fellowship","award":["LT000907\/2012-L"],"award-info":[{"award-number":["LT000907\/2012-L"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Sequencing pools of individuals (Pool-Seq) is a cost-effective way to gain insight into the genetics of complex traits, but as yet no parametric method has been developed to both test for genetic effects and estimate their magnitude. Here, we propose GWAlpha, a flexible method to obtain parametric estimates of genetic effects genome-wide from Pool-Seq experiments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We showed that GWAlpha powerfully replicates the results of Genome-Wide Association Studies (GWAS) from model organisms. We perform simulation studies that illustrate the effect on power of sample size and number of pools and test the method on different experimental data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>GWAlpha is implemented in python, designed to run on Linux operating system and tested on Mac OS. It is freely available at https:\/\/github.com\/aflevel\/GWAlpha.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw805","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T12:09:51Z","timestamp":1481803791000},"page":"1246-1247","source":"Crossref","is-referenced-by-count":3,"title":["GWAlpha: genome-wide estimation of additive effects (alpha) based on trait quantile distribution from pool-sequencing experiments"],"prefix":"10.1093","volume":"33","author":[{"given":"Alexandre","family":"Fournier-Level","sequence":"first","affiliation":[{"name":"School of BioSciences and Centre for Systems Genomics, The University of Melbourne, Parkville, Australia"}]},{"given":"Charles","family":"Robin","sequence":"additional","affiliation":[{"name":"School of BioSciences and Centre for Systems Genomics, The University of Melbourne, Parkville, Australia"}]},{"given":"David J","family":"Balding","sequence":"additional","affiliation":[{"name":"School of BioSciences and Centre for Systems Genomics, The University of Melbourne, Parkville, Australia"},{"name":"School of Mathematics and Statistics, The University of Melbourne, Parkville, Australia"}]}],"member":"286","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"2023020205023478100_btw805-B1","first-page":"2573","author":"Battlay","year":"2016"},{"key":"2023020205023478100_btw805-B2","doi-asserted-by":"crossref","first-page":"e1001193","DOI":"10.1371\/journal.pgen.1001193","article-title":"A coastal cline in sodium accumulation in Arabidopsis thaliana is driven by natural variation of the sodium transporter AtHKT1;1","volume":"6","author":"Baxter","year":"2010","journal-title":"Plos Genet"},{"key":"2023020205023478100_btw805-B3","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1073\/pnas.1421416112","article-title":"Coselected genes determine adaptive variation in herbivore resistance throughout the native range of Arabidopsis thaliana","volume":"112","author":"Brachi","year":"2015","journal-title":"Proc. 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Biol"},{"key":"2023020205023478100_btw805-B8","doi-asserted-by":"crossref","first-page":"e1003057.","DOI":"10.1371\/journal.pgen.1003057","article-title":"Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving viruses in Drosophila melanogaster","volume":"8","author":"Magwire","year":"2012","journal-title":"PLoS Genet"},{"key":"2023020205023478100_btw805-B9","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nrg3803","article-title":"Sequencing pools of individuals\u2014mining genome-wide polymorphism data without big funding","volume":"15","author":"Schl\u00f6tterer","year":"2014","journal-title":"Nat. Rev. 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