{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:56:39Z","timestamp":1762761399549},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T00:00:00Z","timestamp":1484956800000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"KNOW RNA Research Centre","award":["01\/KNOW2\/2014"],"award-info":[{"award-number":["01\/KNOW2\/2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>ORCAN (ORtholog sCANner) is a web-based meta-server for one-click evolutionary and functional annotation of protein sequences. The server combines information from the most popular orthology-prediction resources, including four tools and four online databases. Functional annotation utilizes five additional comparisons between the query and identified homologs, including: sequence similarity, protein domain architectures, functional motifs, Gene Ontology term assignments and a list of associated articles. Furthermore, the server uses a plurality-based rating system to evaluate the orthology relationships and to rank the reference proteins by their evolutionary and functional relevance to the query. Using a dataset of \u223c1 million true yeast orthologs as a sample reference set, we show that combining multiple orthology-prediction tools in ORCAN increases the sensitivity and precision by 1\u20132 percent points.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>The service is available for free at http:\/\/www.combio.pl\/orcan\/.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw825","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T01:35:34Z","timestamp":1483666534000},"page":"1224-1226","source":"Crossref","is-referenced-by-count":13,"title":["ORCAN\u2014a web-based meta-server for real-time detection and functional annotation of orthologs"],"prefix":"10.1093","volume":"33","author":[{"given":"Andrzej","family":"Zielezinski","sequence":"first","affiliation":[{"name":"Department of Computational Biology, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Dziubek","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sliski","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech M","family":"Karlowski","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,1,5]]},"reference":[{"key":"2023020205022847700_btw825-B1","doi-asserted-by":"crossref","first-page":"D240","DOI":"10.1093\/nar\/gku1158","article-title":"The OMA orthology database in 2015: function predictions, better plant support, synteny view and other improvements","volume":"43","author":"Altenhoff","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2023020205022847700_btw825-B2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nmeth.3830","article-title":"Standardized benchmarking in the quest for orthologs","volume":"13","author":"Altenhoff","year":"2016","journal-title":"Nat. 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