{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:44:42Z","timestamp":1740185082074,"version":"3.37.3"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T00:00:00Z","timestamp":1483574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100000023","name":"Government of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["GPH-129344"],"award-info":[{"award-number":["GPH-129344"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Minist\u00e8re de l"},{"DOI":"10.13039\/100016328","name":"Quebec Breast Cancer Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016328","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>The identification of the functional variants responsible for observed genome-wide association studies (GWAS) signals is one of the most challenging tasks of the post-GWAS research era. Several tools have been developed to annotate genetic variants by their genomic location and potential functional implications. Each of these tools has its own requirements and internal logic, which forces the user to become acquainted with each interface.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From an awareness of the amount of work needed to analyze a single locus, we have built a flexible, versatile and easy-to-use web interface designed to help in prioritizing variants and predicting their potential functional implications. This interface acts as a single-point of entry linking association results with reference tools and relevant experiments.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>VEXOR is an integrative web application implemented through the Shiny framework and available at: http:\/\/romix.genome.ulaval.ca\/vexor.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw826","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T01:20:21Z","timestamp":1486516821000},"page":"1389-1391","source":"Crossref","is-referenced-by-count":2,"title":["VEXOR: an integrative environment for prioritization of functional variants in fine-mapping analysis"],"prefix":"10.1093","volume":"33","author":[{"given":"Audrey","family":"Lema\u00e7on","sequence":"first","affiliation":[{"name":"Genomics Center, Centre Hospitalier Universitaire de Qu\u00e9bec - Universit\u00e9 Laval Research Center, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Joly Beauparlant","sequence":"additional","affiliation":[{"name":"Genomics Center, Centre Hospitalier Universitaire de Qu\u00e9bec - Universit\u00e9 Laval Research Center, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penny","family":"Soucy","sequence":"additional","affiliation":[{"name":"Genomics Center, Centre Hospitalier Universitaire de Qu\u00e9bec - Universit\u00e9 Laval Research Center, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Easton","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK"},{"name":"Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kraft","sequence":"additional","affiliation":[{"name":"Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. 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