{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:34:42Z","timestamp":1772138082253,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>We propose the simple method HLA-MA for consistency checking in pipelines operating on human HTS data. The method is based on the HLA typing result of the state-of-the-art method OptiType. Provided that there is sufficient coverage of the HLA loci, comparing HLA types allows for simple, fast and robust matching of samples from whole genome, exome and RNA-seq data. Our approach uses information from small but genetically highly variable regions and thus complements approaches that rely on genome or exon-wide variant profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and Implementation<\/jats:title>\n                    <jats:p>The software is implemented In Python 3 and freely available under the MIT license at https:\/\/github.com\/bihealth\/hlama and via Bioconda.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx132","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T15:12:28Z","timestamp":1488985948000},"page":"2241-2242","source":"Crossref","is-referenced-by-count":0,"title":["HLA-MA: simple yet powerful matching of samples using HLA typing results"],"prefix":"10.1093","volume":"33","author":[{"given":"Clemens","family":"Messerschmidt","sequence":"first","affiliation":[{"name":"Core Unit Bioinformatics, Berlin Institute of Health, Berlin, Germany"},{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Holtgrewe","sequence":"additional","affiliation":[{"name":"Core Unit Bioinformatics, Berlin Institute of Health, Berlin, Germany"},{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Beule","sequence":"additional","affiliation":[{"name":"Core Unit Bioinformatics, Berlin Institute of Health, Berlin, Germany"},{"name":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"2023051506465570500_btx132-B1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1101\/gr.210500.116","article-title":"A reference dataset of 5. 4 million human variants validated by genetic inheritance from sequencing a three-generation 17-member pedigree","volume":"27","author":"Eberle","year":"2016","journal-title":"Genome Res"},{"key":"2023051506465570500_btx132-B2","doi-asserted-by":"crossref","first-page":"e1004274","DOI":"10.1371\/journal.pcbi.1004274","article-title":"Genome Modeling System: A Knowledge Management Platform for Genomics","volume":"11","author":"Griffith","year":"2015","journal-title":"PLOS Comput. 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