{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:27:32Z","timestamp":1780572452990,"version":"3.54.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T00:00:00Z","timestamp":1492732800000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Motivation<\/jats:title><jats:p>Drug synergies are sought to identify combinations of drugs particularly beneficial. User-friendly software solutions that can assist analysis of large-scale datasets are required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CImbinator is a web-service that can aid in batch-wise and in-depth analyzes of data from small-scale and large-scale drug combination screens. CImbinator offers to quantify drug combination effects, using both the commonly employed median effect equation, as well as advanced experimental mathematical models describing dose response relationships.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and Implementation<\/jats:title><jats:p>CImbinator is written in Ruby and R. It uses the R package drc for advanced drug response modeling. CImbinator is available at http:\/\/cimbinator.bioinfo.cnio.es, the source-code is open and available at https:\/\/github.com\/Rbbt-Workflows\/combination_index. A Docker image is also available at https:\/\/hub.docker.com\/r\/mikisvaz\/rbbt-ci_mbinator\/.<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx161","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T19:01:36Z","timestamp":1490122896000},"page":"2410-2412","source":"Crossref","is-referenced-by-count":17,"title":["CImbinator: a web-based tool for drug synergy analysis in small- and large-scale datasets"],"prefix":"10.1093","volume":"33","author":[{"given":"\u00c5smund","family":"Flobak","sequence":"first","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"},{"name":"Structural Computational Biology Group, Structural Biology and Biocomputing Programme, CNIO (Spanish National Cancer Research Centre), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"L\u00e6greid","sequence":"additional","affiliation":[{"name":"Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Valencia","sequence":"additional","affiliation":[{"name":"Structural Computational Biology Group, Structural Biology and Biocomputing Programme, CNIO (Spanish National Cancer Research Centre), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,19]]},"reference":[{"key":"2023063012505874700_btx161-B1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.18632\/oncotarget.938","article-title":"Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms","volume":"4","author":"Axelrod","year":"2013","journal-title":"Oncotarget"},{"key":"2023063012505874700_btx161-B2","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res"},{"key":"2023063012505874700_btx161-B3","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1126\/science.1254721","article-title":"Patient-derived models of acquired resistance can identify effective drug combinations for cancer","volume":"346","author":"Crystal","year":"2014","journal-title":"Science"},{"key":"2023063012505874700_btx161-B4","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1093\/bioinformatics\/btw230","article-title":"Combenefit: An interactive platform for the analysis and visualisation of drug combinations","volume":"32","author":"Di Veroli","year":"2016","journal-title":"Bioinformatics"},{"key":"2023063012505874700_btx161-B5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0031-6997(25)06847-4","article-title":"The search for synergy: a critical review from a response surface perspective","volume":"47","author":"Greco","year":"1995","journal-title":"Pharmacol. 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