{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:14:37Z","timestamp":1762431277188,"version":"3.37.3"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T00:00:00Z","timestamp":1491523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 CA189205-01"],"award-info":[{"award-number":["U54 CA189205-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>The increasing amount of peer-reviewed manuscripts requires the development of specific mining tools to facilitate the visual exploration of evidence linking diseases and proteins.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We developed TIN-X, the Target Importance and Novelty eXplorer, to visualize the association between proteins and diseases, based on text mining data processed from scientific literature. In the current implementation, TIN-X supports exploration of data for G-protein coupled receptors, kinases, ion channels, and nuclear receptors. TIN-X supports browsing and navigating across proteins and diseases based on ontology classes, and displays a scatter plot with two proposed new bibliometric statistics: Importance and Novelty.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>http:\/\/www.newdrugtargets.org<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx200","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T14:43:48Z","timestamp":1491489828000},"page":"2601-2603","source":"Crossref","is-referenced-by-count":32,"title":["TIN-X: target importance and novelty explorer"],"prefix":"10.1093","volume":"33","author":[{"given":"Daniel C","family":"Cannon","sequence":"first","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA"}]},{"given":"Jeremy J","family":"Yang","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA"}]},{"given":"Stephen L","family":"Mathias","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA"}]},{"given":"Oleg","family":"Ursu","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA"}]},{"given":"Subramani","family":"Mani","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA"}]},{"given":"Anna","family":"Waller","sequence":"additional","affiliation":[{"name":"UNM Center for Molecular Discovery, University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, USA"}]},{"given":"Stephan C","family":"Sch\u00fcrer","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL, USA"}]},{"given":"Lars Juhl","family":"Jensen","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen N, Denmark"}]},{"given":"Larry A","family":"Sklar","sequence":"additional","affiliation":[{"name":"UNM Center for Molecular Discovery, University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, USA"},{"name":"Department of Pathology, University of New Mexico, NM, USA"}]},{"given":"Cristian G","family":"Bologa","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA"}]},{"given":"Tudor I","family":"Oprea","sequence":"additional","affiliation":[{"name":"Translational Informatics Division, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM, USA"}]}],"member":"286","published-online":{"date-parts":[[2017,4,7]]},"reference":[{"key":"2023020206272409100_btx200-B1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.molcel.2006.02.012","article-title":"Biomedical language processing: what\u2019s beyond PubMed?","volume":"21","author":"Hunter","year":"2006","journal-title":"Mol. Cell"},{"key":"2023020206272409100_btx200-B2","doi-asserted-by":"crossref","first-page":"D1071","DOI":"10.1093\/nar\/gku1011","article-title":"Disease ontology 2015 update: an expanded and updated database of human diseases for linking biomedical knowledge through disease data","volume":"43","author":"Kibbe","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2023020206272409100_btx200-B3","doi-asserted-by":"crossref","first-page":"D995","DOI":"10.1093\/nar\/gkw1072","article-title":"Pharos: collating protein information to shed light on the druggable genome","volume":"45","author":"Nguyen","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2023020206272409100_btx200-B4","doi-asserted-by":"crossref","first-page":"e65390.","DOI":"10.1371\/journal.pone.0065390","article-title":"The SPECIES and ORGANISMS resources for fast and accurate identification of taxonomic names in text","volume":"8","author":"Pafilis","year":"2013","journal-title":"PLOS One"},{"key":"2023020206272409100_btx200-B5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ymeth.2014.11.020","article-title":"DISEASES: Text mining and data integration of disease\u2013gene associations","volume":"74","author":"Pletscher-Frankild","year":"2015","journal-title":"Methods"},{"key":"2023020206272409100_btx200-B6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd.2016.230","article-title":"A Comprehensive Map of Molecular Drug Targets","volume":"16","author":"Santos","year":"2017","journal-title":"Nat. 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Drug Discov"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/33\/16\/2601\/49041020\/bioinformatics_33_16_2601.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/33\/16\/2601\/49041020\/bioinformatics_33_16_2601.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T06:29:48Z","timestamp":1675319388000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/33\/16\/2601\/3111842"}},"subtitle":[],"editor":[{"given":"Jonathan","family":"Wren","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2017,4,7]]},"references-count":6,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2017,8,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btx200","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"type":"print","value":"1367-4803"},{"type":"electronic","value":"1367-4811"}],"subject":[],"published-other":{"date-parts":[[2017,8,15]]},"published":{"date-parts":[[2017,4,7]]}}}