{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T07:24:45Z","timestamp":1771745085420,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"NIMH","doi-asserted-by":"publisher","award":["NIH-R01MH101814"],"award-info":[{"award-number":["NIH-R01MH101814"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Genetic loci associated with the variance of phenotypic traits have been of recent interest as they can be signatures of genetic interactions, gene by environment interactions, parent of origin effects and canalization. We present a fast efficient tool to map loci affecting variance of gene expression and other molecular phenotypes in cis. Results: Applied to the publicly available Geuvadis gene expression dataset, we identify 816 loci associated with variance of gene expression using an additive model, and 32 showing differences in variance between homozygous and heterozygous alleles, signatures of parent of origin effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Documentation and links to source code and binaries for linux can be found at https:\/\/funpopgen.github.io\/veqm\/.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx273","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T13:34:25Z","timestamp":1493040865000},"page":"2772-2773","source":"Crossref","is-referenced-by-count":3,"title":["veqtl-mapper: variance association mapping for molecular phenotypes"],"prefix":"10.1093","volume":"33","author":[{"given":"Andrew Anand","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland"},{"name":"Institute of Genetics and Genomics in Geneva, University of Geneva, Geneva, Switzerland"},{"name":"Swiss Institute of Bioinformatics, Geneva, Switzerland"}]}],"member":"286","published-online":{"date-parts":[[2017,4,25]]},"reference":[{"key":"2023020206261052300_btx273-B1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"1000 Genomes Project Consortium","year":"2015","journal-title":"Nature"},{"key":"2023020206261052300_btx273-B2","doi-asserted-by":"crossref","first-page":"e01381","DOI":"10.7554\/eLife.01381","article-title":"Genetic interactions affecting human gene expression identified by variance association mapping","volume":"3","author":"Brown","year":"2014","journal-title":"Elife"},{"key":"2023020206261052300_btx273-B3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1080\/01621459.1974.10482955","article-title":"Robust tests for the equality of variances","volume":"69","author":"Brown","year":"1974","journal-title":"J. Am. Stat. Assoc"},{"key":"2023020206261052300_btx273-B4","first-page":"068635","article-title":"A complete tool set for molecular qtl discovery and analysis","author":"Delaneau","year":"2016","journal-title":"bioRxiv"},{"key":"2023020206261052300_btx273-B5","article-title":"A bayesian test to identify variance effects","author":"Dumitrascu","year":"2015","journal-title":"arXiv Preprint arXiv"},{"key":"2023020206261052300_btx273-B6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/jbg.12174","article-title":"Genetic control of the environmental variance for birth weight in seven generations of a divergent selection experiment in mice","volume":"133","author":"Formoso-Rafferty","year":"2016","journal-title":"J. Anim. Breed. 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