{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:58:25Z","timestamp":1783972705744,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>While growing numbers of T cell receptor (TCR) repertoires are being mapped by high-throughput sequencing, existing methods do not allow for computationally connecting a given TCR sequence to its target antigen, or relating it to a specific pathology. As an alternative, a manually-curated database can relate TCR sequences with their cognate antigens and associated pathologies based on published experimental data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We present McPAS-TCR, a manually curated database of TCR sequences associated with various pathologies and antigens based on published literature. Our database currently contains more than 5000 sequences of TCRs associated with various pathologic conditions (including pathogen infections, cancer and autoimmunity) and their respective antigens in humans and in mice. A web-based tool allows for searching the database based on different criteria, and for finding annotated sequences from the database in users\u2019 data. The McPAS-TCR website assembles information from a large number of studies that is very hard to dissect otherwise. Initial analyses of the data provide interesting insights on pathology-associated TCR sequences.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Free access at http:\/\/friedmanlab.weizmann.ac.il\/McPAS-TCR\/.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx286","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T19:11:22Z","timestamp":1494011482000},"page":"2924-2929","source":"Crossref","is-referenced-by-count":557,"title":["McPAS-TCR: a manually curated catalogue of pathology-associated T cell receptor sequences"],"prefix":"10.1093","volume":"33","author":[{"given":"Nili","family":"Tickotsky","sequence":"first","affiliation":[{"name":"Department of Immunology, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Sagiv","sequence":"additional","affiliation":[{"name":"Department of Immunology, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Prilusky","sequence":"additional","affiliation":[{"name":"Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Shifrut","sequence":"additional","affiliation":[{"name":"Department of Immunology, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Immunology, Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,8]]},"reference":[{"key":"2023020206410515700_btx286-B1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.274.5284.94","article-title":"Phenotypic analysis of antigen-specific T lymphocytes","volume":"274","author":"Altman","year":"1996","journal-title":"Science"},{"key":"2023020206410515700_btx286-B26"},{"key":"2023020206410515700_btx286-B27"},{"key":"2023020206410515700_btx286-B2","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1182\/blood-2013-05-506386","article-title":"Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes","volume":"122","author":"Clemente","year":"2013","journal-title":"Blood"},{"key":"2023020206410515700_btx286-B3","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1172\/JCI82416","article-title":"Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes","volume":"125","author":"Cohen","year":"2015","journal-title":"J. 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