{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:38:28Z","timestamp":1768401508754,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["EMR\/2016\/001476"],"award-info":[{"award-number":["EMR\/2016\/001476"]}],"id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>We have developed PROXiMATE, a database of thermodynamic data for more than 6000 missense mutations in 174 heterodimeric protein\u2013protein complexes, supplemented with interaction network data from STRING database, solvent accessibility, sequence, structural and functional information, experimental conditions and literature information. Additional features include complex structure visualization, search and display options, download options and a provision for users to upload their data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The database is freely available at http:\/\/www.iitm.ac.in\/bioinfo\/PROXiMATE\/. The website is implemented in Python, and supports recent versions of major browsers such as IE10, Firefox, Chrome and Opera.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx312","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T11:09:11Z","timestamp":1494414551000},"page":"2787-2788","source":"Crossref","is-referenced-by-count":72,"title":["PROXiMATE: a database of mutant protein\u2013protein complex thermodynamics and kinetics"],"prefix":"10.1093","volume":"33","author":[{"given":"Sherlyn","family":"Jemimah","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India"}]},{"given":"K","family":"Yugandhar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India"}]},{"given":"M","family":"Michael Gromiha","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India"}]}],"member":"286","published-online":{"date-parts":[[2017,5,11]]},"reference":[{"key":"2023020206270754300_btx312-B1","doi-asserted-by":"crossref","first-page":"e1004494.","DOI":"10.1371\/journal.pcbi.1004494","article-title":"Predicting the Effect of Mutations on Protein-Protein Binding interactions through structure-based interface profiles","volume":"11","author":"Brender","year":"2015","journal-title":"PLoS Comput. 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