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This enables fine-grained analyses of the functions of community members, studies of their association with phenotypes and environments, as well as of their microevolution and adaptation to changing environmental conditions. However, phylogenetic methods for studying adaptation and evolutionary dynamics are not able to cope with big data. EDEN is the first software for the rapid detection of protein families and regions under positive selection, as well as their associated biological processes, from meta- and pangenome data. It provides an interactive result visualization for detailed comparative analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>EDEN is available as a Docker installation under the GPL 3.0 license, allowing its use on common operating systems, at http:\/\/www.github.com\/hzi-bifo\/eden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Contact<\/jats:title><jats:p>alice.mchardy@helmholtz-hzi.de<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx394","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T11:09:16Z","timestamp":1497524956000},"page":"3292-3295","source":"Crossref","is-referenced-by-count":3,"title":["EDEN: evolutionary dynamics within environments"],"prefix":"10.1093","volume":"33","author":[{"given":"Philipp C","family":"M\u00fcnch","sequence":"first","affiliation":[{"name":"Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Brunswick, Germany"},{"name":"Max von Pettenkofer-Institute for Hygiene and Clinical Microbiology, Ludwig-Maximilian University of Munich, Munich , Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Hanover-Brunswick, Brunswick, Germany"}]},{"given":"B\u00e4rbel","family":"Stecher","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer-Institute for Hygiene and Clinical Microbiology, Ludwig-Maximilian University of Munich, Munich , Germany"},{"name":"DZIF, Partner Site LMU Munich, Munich, Germany"}]},{"given":"Alice C","family":"McHardy","sequence":"additional","affiliation":[{"name":"Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Brunswick, Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Hanover-Brunswick, Brunswick, Germany"},{"name":"Department of Algorithmic Bioinformatics, Heinrich Heine University Dusseldorf, Dusseldorf, Germany"},{"name":"Cluster of Excellence on Plant Sciences (CEPLAS), Heinrich Heine University Dusseldorf, Dusseldorf, Germany"}]}],"member":"286","published-online":{"date-parts":[[2017,6,16]]},"reference":[{"key":"2023020207521688700_btx394-B1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/ismej.2015.241","article-title":"Genome-wide selective sweeps and gene-specific sweeps in natural bacterial populations","volume":"10","author":"Bendall","year":"2016","journal-title":"ISME J"},{"key":"2023020207521688700_btx394-B2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. 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