{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:15:27Z","timestamp":1758633327626,"version":"3.37.3"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Motivation<\/jats:title><jats:p>Despite recent advances of modern GWAS methods, it is still remains an important problem of addressing calculation an effect size and corresponding p-value for the whole gene rather than for single variant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We developed an R package rqt, which offers gene-level GWAS meta-analysis. The package can be easily included into bioinformatics pipeline or used stand-alone. We applied this tool to the analysis of Alzheimer\u2019s disease data from three datasets CHS, FHS and LOADFS. Test results from meta-analysis of three Alzheimer studies show its applicability for association testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>The package rqt is freely available under the following link: https:\/\/github.com\/izhbannikov\/rqt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx395","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T03:10:57Z","timestamp":1497409857000},"page":"3129-3130","source":"Crossref","is-referenced-by-count":10,"title":["rqt: an R package for gene-level meta-analysis"],"prefix":"10.1093","volume":"33","author":[{"given":"Ilya Y","family":"Zhbannikov","sequence":"first","affiliation":[{"name":"Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA"}]},{"given":"Konstantin G","family":"Arbeev","sequence":"additional","affiliation":[{"name":"Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA"}]},{"given":"Anatoliy I","family":"Yashin","sequence":"additional","affiliation":[{"name":"Biodemography of Aging Research Unit (BARU), Social Science Research Institute, Duke University, Durham, NC, USA"}]}],"member":"286","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"2023020206472213800_btx395-B1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"2023020206472213800_btx395-B2","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198504405.001.0001","volume-title":"The Genetical Theory of Natural Selection: A Complete Variorum Edition","author":"Fisher","year":"1999"},{"key":"2023020206472213800_btx395-B3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ng.291","article-title":"Common variants at 30 loci contribute to polygenic dyslipidemia","volume":"41","author":"Kathiresan","year":"2009","journal-title":"Nat. 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