{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:23:57Z","timestamp":1777454637209,"version":"3.51.4"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 102-2628-B-002-041-MY3"],"award-info":[{"award-number":["MOST 102-2628-B-002-041-MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 103-2320-B-010-031-MY3"],"award-info":[{"award-number":["MOST 103-2320-B-010-031-MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 104-2628-E-010-001-MY3"],"award-info":[{"award-number":["MOST 104-2628-E-010-001-MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 105-2320-B-002-057-MY3"],"award-info":[{"award-number":["MOST 105-2320-B-002-057-MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 105-2634-E-002-002"],"award-info":[{"award-number":["MOST 105-2634-E-002-002"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Large-scale phosphoproteomics studies have improved our understanding of dynamic cellular signaling, but the downstream analysis of phosphoproteomics data is still a bottleneck. We develop DynaPho, a useful web-based tool providing comprehensive and in-depth analyses of time-course phosphoproteomics data, making analysis intuitive and accessible to non-bioinformatics experts. The tool currently implements five analytic modules, which reveal the transition of biological pathways, kinase activity, dynamics of interaction networks and the predicted kinase-substrate associations. These features can assist users in translating their larger-scale time-course phosphoproteomics data into valuable biological discoveries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>DynaPho is freely available at http:\/\/dynapho.jhlab.tw\/.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx443","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T11:11:39Z","timestamp":1499339499000},"page":"3664-3666","source":"Crossref","is-referenced-by-count":8,"title":["DynaPho: a web platform for inferring the dynamics of time-series phosphoproteomics"],"prefix":"10.1093","volume":"33","author":[{"given":"Chia-Lang","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Life Science, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Genome and Systems Biology Degree Program, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Chun","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsuan-Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsueh-Fen","family":"Juan","sequence":"additional","affiliation":[{"name":"Department of Life Science, National Taiwan University, Taipei, Taiwan"},{"name":"Genome and Systems Biology Degree Program, National Taiwan University, Taipei, Taiwan"},{"name":"Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan"},{"name":"Institute of Molecular and Cellular Biology, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"key":"2023051308382699300_btx443-B1","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1074\/mcp.M115.051383","article-title":"Temporal phosphoproteome dynamics induced by an ATP synthase inhibitor citreoviridin","volume":"14","author":"Hu","year":"2015","journal-title":"Mol. 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Cheminform"},{"key":"2023051308382699300_btx443-B9","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1093\/bioinformatics\/btu572","article-title":"PHOXTRACK-a tool for interpreting comprehensive datasets of post-translational modifications of proteins","volume":"30","author":"Weidner","year":"2014","journal-title":"Bioinformatics"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/33\/22\/3664\/50307438\/bioinformatics_33_22_3664.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/33\/22\/3664\/50307438\/bioinformatics_33_22_3664.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T08:38:41Z","timestamp":1683967121000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/33\/22\/3664\/3933261"}},"subtitle":[],"editor":[{"given":"Jonathan","family":"Wren","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,7,7]]},"references-count":9,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2017,11,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btx443","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,11,15]]},"published":{"date-parts":[[2017,7,7]]}}}