{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T10:43:14Z","timestamp":1748688194875,"version":"3.37.3"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:00:00Z","timestamp":1500249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Polish National Science Centre","doi-asserted-by":"publisher","award":["2014\/13\/B\/NZ2\/03840"],"award-info":[{"award-number":["2014\/13\/B\/NZ2\/03840"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Rule-based modeling is a powerful approach for studying biomolecular site dynamics. Here, we present SPATKIN, a general-purpose simulator for rule-based modeling in two spatial dimensions. The simulation algorithm is a lattice-based method that tracks Brownian motion of individual molecules and the stochastic firing of rule-defined reaction events. Because rules are used as event generators, the algorithm is network-free, meaning that it does not require to generate the complete reaction network implied by rules prior to simulation. In a simulation, each molecule (or complex of molecules) is taken to occupy a single lattice site that cannot be shared with another molecule (or complex). SPATKIN is capable of simulating a wide array of membrane-associated processes, including adsorption, desorption and crowding. Models are specified using an extension of the BioNetGen language, which allows to account for spatial features of the simulated process.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The C\u2009++\u2009source code for SPATKIN is distributed freely under the terms of the GNU GPLv3 license. The source code can be compiled for execution on popular platforms (Windows, Mac and Linux). An installer for 64-bit Windows and a macOS app are available. The source code and precompiled binaries are available at the SPATKIN Web site (http:\/\/pmbm.ippt.pan.pl\/software\/spatkin).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx456","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T19:17:45Z","timestamp":1500059865000},"page":"3667-3669","source":"Crossref","is-referenced-by-count":4,"title":["SPATKIN: a simulator for rule-based modeling of biomolecular site dynamics on surfaces"],"prefix":"10.1093","volume":"33","author":[{"given":"Marek","family":"Kocha\u0144czyk","sequence":"first","affiliation":[{"name":"Institute of Fundamental Technological Research, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S","family":"Hlavacek","sequence":"additional","affiliation":[{"name":"Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Lipniacki","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Technological Research, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,7,17]]},"reference":[{"key":"2023051308381997200_btx456-B1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/bioinformatics\/btw700","article-title":"Smoldyn: particle-based simulation with rule-based modeling, improved molecular interaction, and a library interface","volume":"33","author":"Andrews","year":"2017","journal-title":"Bioinformatics"},{"key":"2023051308381997200_btx456-B2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nmeth.1861","article-title":"Computational modeling of cellular signaling processes embedded into dynamic spatial contexts","volume":"9","author":"Angermann","year":"2012","journal-title":"Nat. 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