{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:21:05Z","timestamp":1773271265144,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>G-quadruplex structures in RNA molecules are known to have regulatory impacts in cells but are difficult to locate in the genome. The minimal requirements for G-quadruplex folding in RNA (G\u22653N1-7\u2009G\u22653N1-7\u2009G\u22653N1-7\u2009G\u22653) is being challenged by observations made on specific examples in recent years. The definition of potential G-quadruplex sequences has major repercussions on the observation of the structure since it introduces a bias. The canonical motif only describes a sub-population of the reported G-quadruplexes. To address these issues, we propose an RNA G-quadruplex prediction strategy that does not rely on a motif definition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We trained an artificial neural network with sequences of experimentally validated G-quadruplexes from the G4RNA database encoded using an abstract definition of their sequence. This artificial neural network, G4NN, evaluates the similarity of a given sequence to known G-quadruplexes and reports it as a score. G4NN has a predictive power comparable to the reported G richness and G\/C skewness evaluations that are the current state-of-the-art for the identification of potential RNA G-quadruplexes. We combined these approaches in the G4RNA screener, a program designed to manage and evaluate the sequences to identify potential G-quadruplexes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>G4RNA screener is available for download at http:\/\/gitlabscottgroup.med.usherbrooke.ca\/J-Michel\/g4rna_screener.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx498","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T19:16:32Z","timestamp":1501614992000},"page":"3532-3537","source":"Crossref","is-referenced-by-count":104,"title":["Motif independent identification of potential RNA G-quadruplexes by G4RNA screener"],"prefix":"10.1093","volume":"33","author":[{"given":"Jean-Michel","family":"Garant","sequence":"first","affiliation":[{"name":"RNA Group\/Groupe ARN, D\u00e9partement de Biochimie, Facult\u00e9 de M\u00e9decine des Sciences de la Sant\u00e9, Pavillon de Recherche Appliqu\u00e9e au Cancer, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada"}]},{"given":"Jean-Pierre","family":"Perreault","sequence":"additional","affiliation":[{"name":"RNA Group\/Groupe ARN, D\u00e9partement de Biochimie, Facult\u00e9 de M\u00e9decine des Sciences de la Sant\u00e9, Pavillon de Recherche Appliqu\u00e9e au Cancer, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada"}]},{"given":"Michelle S","family":"Scott","sequence":"additional","affiliation":[{"name":"RNA Group\/Groupe ARN, D\u00e9partement de Biochimie, Facult\u00e9 de M\u00e9decine des Sciences de la Sant\u00e9, Pavillon de Recherche Appliqu\u00e9e au Cancer, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada"}]}],"member":"286","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"2023051308273025000_btx498-B1","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1039\/C4OB02681K","article-title":"The tale of RNA G-quadruplex","volume":"13","author":"Agarwala","year":"2015","journal-title":"Org. 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