{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:25:13Z","timestamp":1788024313391,"version":"build-2784847793"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000867","name":"CSC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000867","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"MRC","doi-asserted-by":"publisher","award":["MR\/M025411\/1"],"award-info":[{"award-number":["MR\/M025411\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008721","name":"UCLH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"UCL","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>The Illumina Infinium HumanMethylationEPIC BeadChip is the new platform for high-throughput DNA methylation analysis, effectively doubling the coverage compared to the older 450\u2009K array. Here we present a significantly updated and improved version of the Bioconductor package ChAMP, which can be used to analyze EPIC and 450k data. Many enhanced functionalities have been added, including correction for cell-type heterogeneity, network analysis and a series of interactive graphical user interfaces.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>ChAMP is a BioC package available from https:\/\/bioconductor.org\/packages\/release\/bioc\/html\/ChAMP.html.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx513","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T07:08:52Z","timestamp":1502435332000},"page":"3982-3984","source":"Crossref","is-referenced-by-count":937,"title":["ChAMP: updated methylation analysis pipeline for Illumina BeadChips"],"prefix":"10.1093","volume":"33","author":[{"given":"Yuan","family":"Tian","sequence":"first","affiliation":[{"name":"CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai, China"},{"name":"Medical Genomics Group, Paul O\u2019Gorman Building, UCL Cancer Institute, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany J","family":"Morris","sequence":"additional","affiliation":[{"name":"Cambridge Epigenetix, Jonas Webb Building, Babraham Campus, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy P","family":"Webster","sequence":"additional","affiliation":[{"name":"Medical Genomics Group, Paul O\u2019Gorman Building, UCL Cancer Institute, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[{"name":"CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Beck","sequence":"additional","affiliation":[{"name":"Medical Genomics Group, Paul O\u2019Gorman Building, UCL Cancer Institute, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Feber","sequence":"additional","affiliation":[{"name":"Medical Genomics Group, Paul O\u2019Gorman Building, UCL Cancer Institute, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E","family":"Teschendorff","sequence":"additional","affiliation":[{"name":"CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, University of Chinese Academy of Science, Chinese Academy of Sciences, Shanghai, China"},{"name":"Statistical Genomics, UCL Cancer Institute, University College London, London, UK"},{"name":"Department of Women\u2019s Cancer, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"2023020207505630600_btx513-B1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive bioconductor package for the analysis of infinium DNA methylation 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