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Drawing on an extensive feature set, FATHMM-XF outperforms competitors on benchmark tests, particularly in non-coding regions where the majority of pathogenic mutations are likely to be found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>The FATHMM-XF web server is available at http:\/\/fathmm.biocompute.org.uk\/fathmm-xf\/, and as tracks on the Genome Tolerance Browser: http:\/\/gtb.biocompute.org.uk. Predictions are provided for human genome version GRCh37\/hg19. The data used for this project can be downloaded from: http:\/\/fathmm.biocompute.org.uk\/fathmm-xf\/<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx536","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T19:11:27Z","timestamp":1504552287000},"page":"511-513","source":"Crossref","is-referenced-by-count":462,"title":["FATHMM-XF: accurate prediction of pathogenic point mutations via extended features"],"prefix":"10.1093","volume":"34","author":[{"given":"Mark F","family":"Rogers","sequence":"first","affiliation":[{"name":"Intelligent Systems Laboratory, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashem A","family":"Shihab","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Mort","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N","family":"Cooper","sequence":"additional","affiliation":[{"name":"Institute of Medical Genetics, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom R","family":"Gaunt","sequence":"additional","affiliation":[{"name":"MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Campbell","sequence":"additional","affiliation":[{"name":"Intelligent Systems Laboratory, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"2023012712315806500_btx536-B1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/nbt1010-1045","article-title":"The NIH roadmap epigenomics mapping consortium","volume":"28","author":"Bernstein","year":"2010","journal-title":"Nat. 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