{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:36:01Z","timestamp":1761863761316,"version":"3.37.3"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Summary<\/jats:title><jats:p>The R package biospear allows selecting the biomarkers with the strongest impact on survival and on the treatment effect in high-dimensional Cox models, and estimating expected survival probabilities. Most of the implemented approaches are based on penalized regression techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>The package is available on the CRAN. (https:\/\/CRAN.R-project.org\/package=biospear)<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx560","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T11:24:13Z","timestamp":1504610653000},"page":"112-113","source":"Crossref","is-referenced-by-count":16,"title":["biospear: an R package for biomarker selection in penalized Cox regression"],"prefix":"10.1093","volume":"34","author":[{"given":"Nils","family":"Tern\u00e8s","sequence":"first","affiliation":[{"name":"Gustave Roussy, Universit\u00e9 Paris-Saclay, Service de biostatistique et d\u2019\u00e9pid\u00e9miologie, Villejuif, France"},{"name":"Universit\u00e9 Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France"}]},{"given":"Federico","family":"Rotolo","sequence":"additional","affiliation":[{"name":"Gustave Roussy, Universit\u00e9 Paris-Saclay, Service de biostatistique et d\u2019\u00e9pid\u00e9miologie, Villejuif, France"},{"name":"Universit\u00e9 Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6963-2968","authenticated-orcid":false,"given":"Stefan","family":"Michiels","sequence":"additional","affiliation":[{"name":"Gustave Roussy, Universit\u00e9 Paris-Saclay, Service de biostatistique et d\u2019\u00e9pid\u00e9miologie, Villejuif, France"},{"name":"Universit\u00e9 Paris-Saclay, Univ. 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