{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T14:00:31Z","timestamp":1774879231675,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"Abstract<\/jats:title>\n \n Motivation<\/jats:title>\n Existing approaches to plot association results from genome-wide association studies (GWAS) are in the form of static Manhattan plots and often lack data integration with rich databases on variant regulatory potential as well as population-specific linkage disequilibrium patterns.<\/jats:p>\n <\/jats:sec>\n \n Summary<\/jats:title>\n We created an intuitive web module for uploading and efficiently exploring GWAS association results. Interactive plots and sortable tables allow researchers to query genomic regions of interest, facilitating the integration of data on linkage disequilibrium, variant regulatory potential and potential target genes. External links allow for visualization of association results in the UCSC genome browser as well as easy access to publically available databases (e.g. dbSNP and RegulomeDB). Through improved visualization and data integration, LDassoc offers genomic researchers a specialized environment to examine association signals and suggests variants for functional investigation.<\/jats:p>\n <\/jats:sec>\n \n Availability and implementation<\/jats:title>\n LDassoc is a free and publically available web tool which can be accessed online at https:\/\/analysistools.nci.nih.gov\/LDlink\/? tab=ldassoc.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx561","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T19:11:19Z","timestamp":1504638679000},"page":"887-889","source":"Crossref","is-referenced-by-count":105,"title":["LDassoc: an online tool for interactively exploring genome-wide association study results and prioritizing variants for functional investigation"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6538-9705","authenticated-orcid":false,"given":"Mitchell J","family":"Machiela","sequence":"first","affiliation":[]},{"given":"Stephen J","family":"Chanock","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"2023012712460128600_btx561-B1","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using RegulomeDB","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res"},{"key":"2023012712460128600_btx561-B2","first-page":"193","volume-title":"World Cancer Report 2014","author":"Chanock","year":"2014"},{"key":"2023012712460128600_btx561-B3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13029-015-0032-8","article-title":"LocusTrack: integrated visualization of GWAS results and genomic annotation","volume":"10","author":"Cuellar-Partida","year":"2015","journal-title":"Source Code Biol. Med"},{"key":"2023012712460128600_btx561-B4","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1093\/bioinformatics\/btv690","article-title":"LocusExplorer: a user-friendly tool for integrated visualization of human genetic association data and biological annotations","volume":"32","author":"Dadaev","year":"2016","journal-title":"Bioinformatics"},{"key":"2023012712460128600_btx561-B5","doi-asserted-by":"crossref","first-page":"D896","DOI":"10.1093\/nar\/gkw1133","article-title":"The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)","volume":"45","author":"MacArthur","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2023012712460128600_btx561-B6","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1093\/bioinformatics\/btv402","article-title":"LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants","volume":"31","author":"Machiela","year":"2015","journal-title":"Bioinformatics"},{"key":"2023012712460128600_btx561-B7","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/bioinformatics\/btq419","article-title":"LocusZoom: regional visualization of genome-wide association scan results","volume":"26","author":"Pruim","year":"2010","journal-title":"Bioinformatics"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/5\/887\/48913475\/bioinformatics_34_5_887.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/5\/887\/48913475\/bioinformatics_34_5_887.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T12:48:36Z","timestamp":1674823716000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/34\/5\/887\/4124856"}},"subtitle":[],"editor":[{"given":"Oliver","family":"Stegle","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2017,9,12]]},"references-count":7,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btx561","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,3,1]]},"published":{"date-parts":[[2017,9,12]]}}}