{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:04:11Z","timestamp":1784786651959,"version":"3.55.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01GM104400"],"award-info":[{"award-number":["R01GM104400"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Label propagation and diffusion over biological networks are a common mathematical formalism in computational biology for giving context to molecular entities and prioritizing novel candidates in the area of study. There are several choices in conceiving the diffusion process\u2014involving the graph kernel, the score definitions and the presence of a posterior statistical normalization\u2014which have an impact on the results. This manuscript describes diffuStats, an R package that provides a collection of graph kernels and diffusion scores, as well as a parallel permutation analysis for the normalized scores, that eases the computation of the scores and their benchmarking for an optimal choice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The R package diffuStats is publicly available in Bioconductor, https:\/\/bioconductor.org, under the GPL-3 license.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx632","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T19:22:08Z","timestamp":1507144928000},"page":"533-534","source":"Crossref","is-referenced-by-count":33,"title":["diffuStats: an R package to compute diffusion-based scores on biological networks"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-8204","authenticated-orcid":false,"given":"Sergio","family":"Picart-Armada","sequence":"first","affiliation":[{"name":"B2SLab, Departament d\u2019Enginyeria de Sistemes, Autom\u00e0tica i Inform\u00e0tica Industrial, Universitat Polit\u00e8cnica de Catalunya, CIBER-BBN, Barcelona, Spain"},{"name":"Department of Biomedical Engineering, Institut de Recerca Pedi\u00e0trica Hospital Sant Joan de D\u00e9u, Esplugues de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley K","family":"Thompson","sequence":"additional","affiliation":[{"name":"Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Roskilde, Denmark"},{"name":"Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Buil","sequence":"additional","affiliation":[{"name":"Institute of Biological Psychiatry, Mental Health Center Sct. 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