{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T06:08:24Z","timestamp":1674886104556},"reference-count":3,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>VizGVar was designed to meet the growing need of the research community for improved genomic and proteomic data viewers that benefit from better information visualization.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We implemented a new information architecture and applied user centered design principles to provide a new improved way of visualizing genetic information and protein data related to human disease. VizGVar connects the entire database of Ensembl protein motifs, domains, genes and exons with annotated SNPs and somatic variations from PharmGKB and COSMIC. VizGVar precisely represents genetic variations and their respective location by colored curves to designate different types of variations. The structured hierarchy of biological data is reflected in aggregated patterns through different levels, integrating several layers of information at once. VizGVar provides a new interactive, web-based JavaScript visualization of somatic mutations and protein variation, enabling fast and easy discovery of clinically relevant variation patterns.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>VizGVar is accessible at http:\/\/vizport.io\/vizgvar; http:\/\/vizport.io\/vizgvar\/doc\/.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx694","type":"journal-article","created":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T11:09:10Z","timestamp":1509188950000},"page":"1048-1049","source":"Crossref","is-referenced-by-count":1,"title":["Visualization portal for genetic variation (VizGVar): a tool for interactive visualization of SNPs and somatic mutations in exons, genes and protein domains"],"prefix":"10.1093","volume":"34","author":[{"given":"Antonio","family":"Solano-Rom\u00e1n","sequence":"first","affiliation":[{"name":"Department of Industrial Design Engineering, Costa Rica Institute of Technology (TEC), Cartago, Costa Rica"},{"name":"Department of Art + Design, Northeastern University, Boston, MA, USA"}]},{"given":"Ver\u00f3nica","family":"Alfaro-Arias","sequence":"additional","affiliation":[{"name":"Department of Industrial Design Engineering, Costa Rica Institute of Technology (TEC), Cartago, Costa Rica"}]},{"given":"Carlos","family":"Cruz-Castillo","sequence":"additional","affiliation":[{"name":"CENFOTEC University, San Jos\u00e9, Costa Rica"}]},{"given":"Allan","family":"Orozco-Solano","sequence":"additional","affiliation":[{"name":"School of Health Technologies, Faculty of Medicine, University of Costa Rica, San Pedro de Montes de Oca, San Jos\u00e9, Costa Rica"},{"name":"Department of Molecular Biology, Autonomous University of Madrid, Cantoblanco, Madrid, Spain"}]}],"member":"286","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"2023012712464421700_btx694-B1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/bioinformatics\/btt614","article-title":"Sequence alignment visualization in HTML5 without Java","volume":"30","author":"Gille","year":"2014","journal-title":"Bioinformatics"},{"key":"2023012712464421700_btx694-B3","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1093\/bioinformatics\/btw119","article-title":"Visual Omics Explorer (VOE): a cross-platform portal for interactive data visualization","volume":"32","author":"Kim","year":"2016","journal-title":"Bioinformatics"},{"key":"2023012712464421700_btx694-B4","volume-title":"Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation","author":"Lam","year":"2013"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/6\/1048\/48913549\/bioinformatics_34_6_1048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/6\/1048\/48913549\/bioinformatics_34_6_1048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T12:48:59Z","timestamp":1674823739000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/34\/6\/1048\/4582278"}},"subtitle":[],"editor":[{"given":"Alfonso","family":"Valencia","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2017,10,30]]},"references-count":3,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,3,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btx694","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,3,15]]},"published":{"date-parts":[[2017,10,30]]}}}