{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T18:47:07Z","timestamp":1769971627224,"version":"3.49.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C12292\/A20861 & C1287\/A16563"],"award-info":[{"award-number":["C12292\/A20861 & C1287\/A16563"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203477\/B\/16\/Z"],"award-info":[{"award-number":["203477\/B\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>The collection, management and visualization of clinical pedigree (family history) data is a core activity in clinical genetics centres. However, clinical pedigree datasets can be difficult to manage, as they are time consuming to capture, and can be difficult to build, manipulate and visualize graphically. Several standalone graphical pedigree editors and drawing applications exist but there are no freely available lightweight graphical pedigree editors that can be easily configured and incorporated into web applications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We developed \u2018pedigreejs\u2019, an interactive graphical pedigree editor written in JavaScript, which uses standard pedigree nomenclature. Pedigreejs provides an easily configurable, extensible and lightweight pedigree editor. It makes use of an open-source Javascript library to define a hierarchical layout and to produce images in scalable vector graphics (SVG) format that can be viewed and edited in web browsers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The software is freely available under GPL licence (https:\/\/ccge-boadicea.github.io\/pedigreejs\/).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx705","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T12:09:27Z","timestamp":1509365367000},"page":"1069-1071","source":"Crossref","is-referenced-by-count":12,"title":["pedigreejs: a web-based graphical pedigree editor"],"prefix":"10.1093","volume":"34","author":[{"given":"Tim","family":"Carver","sequence":"first","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK"}]},{"given":"Alex P","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK"}]},{"given":"Chantal","family":"Babb de Villiers","sequence":"additional","affiliation":[{"name":"The Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK"}]},{"given":"Andrew","family":"Lee","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK"}]},{"given":"Simon","family":"Hartley","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK"}]},{"given":"Marc","family":"Tischkowitz","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK"}]},{"given":"Fiona M","family":"Walter","sequence":"additional","affiliation":[{"name":"The Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK"}]},{"given":"Douglas F","family":"Easton","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK"},{"name":"Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK"}]},{"given":"Antonis C","family":"Antoniou","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK"}]}],"member":"286","published-online":{"date-parts":[[2017,10,31]]},"reference":[{"key":"2023012712470021700_btx705-B1","first-page":"745","article-title":"Recommendations for standardized human pedigree nomenclature. Pedigree Standardization Task Force of the National Society of Genetic Counselors","volume":"56","author":"Bennett","year":"1995","journal-title":"Am. J. Hum. Genet"},{"key":"2023012712470021700_btx705-B2","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s10897-008-9169-9","article-title":"Standardized human pedigree nomenclature: update and assessment of the recommendations of the National Society of Genetic Counselors","volume":"17","author":"Bennett","year":"2008","journal-title":"J. Genet. Couns"},{"key":"2023012712470021700_btx705-B3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation PLINK: rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"Gigascience"},{"key":"2023012712470021700_btx705-B4","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1093\/bioinformatics\/bth231","article-title":"Pelican: pedigree editor for linkage computer analysis","volume":"20","author":"Dudbridge","year":"2004","journal-title":"Bioinformatics"},{"key":"2023012712470021700_btx705-B5","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/humu.22347","article-title":"PhenoTips: patient phenotyping software for clinical and research use","volume":"34","author":"Girdea","year":"2013","journal-title":"Hum. Mutat"},{"key":"2023012712470021700_btx705-B6","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/bjc.2013.730","article-title":"BOADICEA breast cancer risk prediction model: updates to cancer incidences, tumour pathology and web interface","volume":"110","author":"Lee","year":"2014","journal-title":"Br. J. Cancer"},{"key":"2023012712470021700_btx705-B7","author":"NICE","year":"2013"},{"key":"2023012712470021700_btx705-B8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000363105","article-title":"The kinship2 R package for pedigree data","volume":"78","author":"Sinnwell","year":"2014","journal-title":"Hum. Hered"},{"key":"2023012712470021700_btx705-B9","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/sim.1668","article-title":"A breast cancer prediction model incorporating familial and personal risk factors","volume":"23","author":"Tyrer","year":"2004","journal-title":"Stat. Med"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/6\/1069\/48913707\/bioinformatics_34_6_1069.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/6\/1069\/48913707\/bioinformatics_34_6_1069.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T13:39:15Z","timestamp":1674826755000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/34\/6\/1069\/4583632"}},"subtitle":[],"editor":[{"given":"Oliver","family":"Stegle","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2017,10,31]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,3,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btx705","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,3,15]]},"published":{"date-parts":[[2017,10,31]]}}}