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We recently developed a new high-throughput platform for mapping chemical-genetic (CG) interactions in yeast that can be scaled to screen large compound collections, and we applied this system to generate CG interaction profiles for more than 13\u00a0000 compounds. When integrated with the existing global yeast genetic interaction network, CG interaction profiles can enable mode-of-action prediction for previously uncharacterized compounds as well as discover unexpected secondary effects for known drugs. To facilitate future analysis of these valuable data, we developed a public database and web interface named MOSAIC. The website provides a convenient interface for querying compounds, bioprocesses (Gene Ontology terms) and genes for CG information including direct CG interactions, bioprocesses and gene-level target predictions. MOSAIC also provides access to chemical structure information of screened molecules, chemical-genomic profiles and the ability to search for compounds sharing structural and functional similarity. This resource will be of interest to chemical biologists for discovering new small molecule probes with specific modes-of-action as well as computational biologists interested in analysing CG interaction networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>MOSAIC is available at http:\/\/mosaic.cs.umn.edu.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx732","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:50:11Z","timestamp":1511977811000},"page":"1251-1252","source":"Crossref","is-referenced-by-count":15,"title":["MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action"],"prefix":"10.1093","volume":"34","author":[{"given":"Justin","family":"Nelson","sequence":"first","affiliation":[{"name":"Bioinformatics and Computational Biology Program, University of Minnesota-Twin Cities, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott W","family":"Simpkins","sequence":"additional","affiliation":[{"name":"Bioinformatics and Computational Biology Program, University of Minnesota-Twin Cities, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid","family":"Safizadeh","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, MN, USA"},{"name":"Department of Electrical and Computer Engineering, University of Minnesota-Twin Cities, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5759-8117","authenticated-orcid":false,"given":"Sheena C","family":"Li","sequence":"additional","affiliation":[{"name":"RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff S","family":"Piotrowski","sequence":"additional","affiliation":[{"name":"Yumanity Therapeutics, Cambridge, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Hirano","sequence":"additional","affiliation":[{"name":"RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Yashiroda","sequence":"additional","affiliation":[{"name":"RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Osada","sequence":"additional","affiliation":[{"name":"RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Yoshida","sequence":"additional","affiliation":[{"name":"RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Boone","sequence":"additional","affiliation":[{"name":"RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan"},{"name":"University of Toronto, Donnelly Centre, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad L","family":"Myers","sequence":"additional","affiliation":[{"name":"Bioinformatics and Computational Biology Program, University of Minnesota-Twin Cities, Minneapolis, MN, USA"},{"name":"Department of Computer Science and Engineering, University of Minnesota-Twin Cities, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,11,30]]},"reference":[{"key":"2023012713003666000_btx732-B1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1126\/science.1180823","article-title":"The genetic landscape of a cell","volume":"327","author":"Costanzo","year":"2010","journal-title":"Science"},{"key":"2023012713003666000_btx732-B2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/6791","article-title":"Genomic profiling of drug sensitivities via induced haploinsufficiency","volume":"21","author":"Giaever","year":"1999","journal-title":"Nat. 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