{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:19:17Z","timestamp":1775470757682,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T00:00:00Z","timestamp":1513987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61622213"],"award-info":[{"award-number":["61622213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61370024"],"award-info":[{"award-number":["61370024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61420106009"],"award-info":[{"award-number":["61420106009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>The molecular interactions in a cell are varying with time and surrounded environmental cues. The construction and analysis of dynamic molecular networks can elucidate dynamic cellular mechanisms of different biological functions and provide a chance to understand complex diseases at the systems level. Here, we develop DyNetViewer, a Cytoscape application that provides a range of functionalities for the construction, analysis and visualization of dynamic protein\u2013protein interaction networks. The current version of DyNetViewer consists of four different dynamic network construction methods, twelve topological variation analysis methods and four clustering algorithms. Moreover, visualization of different topological variation of nodes and clusters over time enables users to quickly identify the most variations across many network states.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>DyNetViewer is freely available with tutorials at the Cytoscape (3.4+) App Store (http:\/\/apps.cytoscape.org\/apps\/dynetviewer).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx821","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T20:15:09Z","timestamp":1513973709000},"page":"1597-1599","source":"Crossref","is-referenced-by-count":30,"title":["DyNetViewer: a Cytoscape app for dynamic network construction, analysis and visualization"],"prefix":"10.1093","volume":"34","author":[{"given":"Min","family":"Li","sequence":"first","affiliation":[{"name":"School of Information Science and Engineering, Central South University, Changsha, China"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Information Science and Engineering, Central South University, Changsha, China"}]},{"given":"Fang-Xiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, Canada"}]},{"given":"Yi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Georgia State University, Atlanta, GA, USA"}]},{"given":"Jianxin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Information Science and Engineering, Central South University, Changsha, China"}]}],"member":"286","published-online":{"date-parts":[[2017,12,23]]},"reference":[{"key":"2023012713031681600_btx821-B1","doi-asserted-by":"crossref","first-page":"2.","DOI":"10.1186\/1471-2105-4-2","article-title":"An automated method for finding molecular complexes in large protein interaction networks","volume":"4","author":"Bader","year":"2003","journal-title":"BMC Bioinformatics"},{"key":"2023012713031681600_btx821-B2","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1093\/bioinformatics\/btr273","article-title":"TVNViewer: an interactive visualization tool for exploring networks that change over time or space","volume":"27","author":"Curtis","year":"2011","journal-title":"Bioinformatics"},{"key":"2023012713031681600_btx821-B3","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1093\/bioinformatics\/btw187","article-title":"DyNet: visualization and analysis of dynamic molecular interaction networks","volume":"32","author":"Goenawan","year":"2016","journal-title":"Bioinformatics"},{"key":"2023012713031681600_btx821-B4","doi-asserted-by":"crossref","first-page":"3799.","DOI":"10.1038\/srep03799","article-title":"Characterizing and controlling the inflammatory network during influenza A virus infection","volume":"4","author":"Jin","year":"2015","journal-title":"Sci. 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