{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:33:36Z","timestamp":1785198816044,"version":"3.55.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61402190, 61532008 and 61602309"],"award-info":[{"award-number":["61402190, 61532008 and 61602309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>We develop DiffGraph, an R package that integrates four influential differential graphical models for identifying gene network rewiring under two different conditions from gene expression data. The input and output of different models are packaged in the same format, making it convenient for users to compare different models using a wide range of datasets and carry out follow-up analysis. Furthermore, the inferred differential networks can be visualized both non-interactively and interactively. The package is useful for identifying gene network rewiring from input datasets, comparing the predictions of different methods and visualizing the results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The package is available at https:\/\/github.com\/Zhangxf-ccnu\/DiffGraph.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx836","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T04:56:25Z","timestamp":1513918585000},"page":"1571-1573","source":"Crossref","is-referenced-by-count":14,"title":["DiffGraph: an R package for identifying gene network rewiring using differential graphical models"],"prefix":"10.1093","volume":"34","author":[{"given":"Xiao-Fei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Statistics, School of Mathematics and Statistics, Central China Normal University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Ou-Yang","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, College of Information Engineering, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Wuhan Number 1 Hospital, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Computer Science, School of Computer, Central China Normal University, Wuhan, China"},{"name":"Department of Information Science, College of Computing and Informatics, Drexel University, Philadelphia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"2023012713020828200_btx836-B1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/rssb.12033","article-title":"The joint graphical lasso for inverse covariance estimation across multiple classes","volume":"76","author":"Danaher","year":"2014","journal-title":"J. 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