{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:27:38Z","timestamp":1792801658557,"version":"4.5.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T00:00:00Z","timestamp":1514419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Size-exclusion chromatography (SEC) coupled to small-angle X-ray scattering (SAXS), also known as inline SEC-SAXS, is being increasingly used for the structural analysis of biological macromolecules, complexes and mixtures in solution. A single SEC-SAXS run generates thousands of individual SAXS profiles from the eluting solute and their analysis requires a correct identification of buffer and sample regions, a rather laborous task. We present CHROMIXS (as in CHROMatography Inline X-ray Scattering), a program for rapid reduction and analysis, both automatically and interactively, of SEC-SAXS data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>CHROMIXS is freely available to academic users as part of the ATSAS software suite (www.embl-hamburg.de\/biosaxs\/download.html).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btx846","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T15:18:30Z","timestamp":1514387910000},"page":"1944-1946","source":"Crossref","is-referenced-by-count":334,"title":["CHROMIXS: automatic and interactive analysis of chromatography-coupled small-angle X-ray scattering data"],"prefix":"10.1093","volume":"34","author":[{"given":"Alejandro","family":"Panjkovich","sequence":"first","affiliation":[{"name":"European Molecular Biology Laboratory, Hamburg Outstation, EMBL c\/o DESY, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitri I","family":"Svergun","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, Hamburg Outstation, EMBL c\/o DESY, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,28]]},"reference":[{"key":"2023012713562351900_btx846-B1","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1107\/S1600576716011201","article-title":"US-SOMO HPLC-SAXS module: dealing with capillary fouling and extraction of pure component patterns from poorly resolved SEC-SAXS data","volume":"49","author":"Brookes","year":"2016","journal-title":"J. Appl. Crystallography"},{"key":"2023012713562351900_btx846-B2","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1107\/S1600576717007786","article-title":"ATSAS 2.8: a comprehensive data analysis suite for small-angle scattering from macromolecular solutions","volume":"50","author":"Franke","year":"2017","journal-title":"J. Appl. Crystallography"},{"key":"2023012713562351900_btx846-B3","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1107\/S1600576717011438","article-title":"BioXTAS RAW: improvements to a free open-source program for small-angle X-ray scattering data reduction and analysis","volume":"50","author":"Hopkins","year":"2017","journal-title":"J. Appl. Crystallography"},{"key":"2023012713562351900_btx846-B4","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1038\/nprot.2016.113","article-title":"Preparing monodisperse macromolecular samples for successful biological small-angle X-ray and neutron-scattering experiments","volume":"11","author":"Jeffries","year":"2016","journal-title":"Nat. Protocols"},{"key":"2023012713562351900_btx846-B5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.abb.2016.02.029","article-title":"Analysis of biostructural changes, dynamics, and interactions\u2013small-angle X-ray scattering to the rescue","volume":"602","author":"Vestergaard","year":"2016","journal-title":"Arch Biochem. Biophys"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/11\/1944\/48937785\/bioinformatics_34_11_1944.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/11\/1944\/48937785\/bioinformatics_34_11_1944.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T08:57:00Z","timestamp":1674809820000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/34\/11\/1944\/4781099"}},"subtitle":[],"editor":[{"given":"Alfonso","family":"Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,12,28]]},"references-count":5,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btx846","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,6,1]]},"published":{"date-parts":[[2017,12,28]]}}}