{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:22:57Z","timestamp":1773098577151,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["317\/13"],"award-info":[{"award-number":["317\/13"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"ISF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003975","name":"Israel Cancer Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003975","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"ERC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Large-scale publicly available genomic data on many disease phenotypes could improve our understanding of the molecular basis of disease. Tools that undertake this challenge by jointly analyzing multiple phenotypes are needed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>ADEPTUS is a web-tool that enables various functional genomics analyses based on a high-quality curated database spanning &amp;gt;38, 000 gene expression profiles and &amp;gt;100 diseases. It offers four types of analysis. (i) For a gene list provided by the user it computes disease ontology (DO), pathway, and gene ontology (GO) enrichment and displays the genes as a network. (ii) For a given disease, it enables exploration of drug repurposing by creating a gene network summarizing the genomic events in it. (iii) For a gene of interest, it generates a report summarizing its behavior across several studies. (iv) It can predict the tissue of origin and the disease of a sample based on its gene expression or its somatic mutation profile. Such analyses open novel ways to understand new datasets and to predict primary site of cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Data and tool: http:\/\/adeptus.cs.tau.ac.il\/home Analyses: Supplementary Material.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty027","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T20:27:50Z","timestamp":1516307270000},"page":"1959-1961","source":"Crossref","is-referenced-by-count":8,"title":["ADEPTUS: a discovery tool for disease prediction, enrichment and network analysis based on profiles from many diseases"],"prefix":"10.1093","volume":"34","author":[{"given":"David","family":"Amar","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Stanford University, Stanford, CA, USA"},{"name":"The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel"}]},{"given":"Amir","family":"Vizel","sequence":"additional","affiliation":[{"name":"The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel"}]},{"given":"Carmit","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}]},{"given":"Ron","family":"Shamir","sequence":"additional","affiliation":[{"name":"The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel"}]}],"member":"286","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"key":"2023012713552882200_bty027-B1","doi-asserted-by":"crossref","first-page":"7779","DOI":"10.1093\/nar\/gkv810","article-title":"Integrated analysis of numerous heterogeneous gene expression profiles for detecting robust disease-specific biomarkers and proposing drug targets","volume":"43","author":"Amar","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2023012713552882200_bty027-B2","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1038\/onc.2016.489","article-title":"Utilizing somatic mutation data from numerous studies for cancer research: proof of concept and applications","volume":"36","author":"Amar","year":"2017","journal-title":"Oncogene"},{"key":"2023012713552882200_bty027-B3","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/ncb3399","article-title":"Melanoma miRNA trafficking controls tumour primary niche formation","volume":"18","author":"Dror","year":"2016","journal-title":"Nat. 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