{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:44:31Z","timestamp":1767015871731,"version":"3.37.3"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"Department of Science and Technology, Government of India","award":["INT\/RUS\/RSF\/P-09"],"award-info":[{"award-number":["INT\/RUS\/RSF\/P-09"]}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["16-44-02002"],"award-info":[{"award-number":["16-44-02002"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Human Resource and Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Existing sources of experimental mutation data do not consider the structural environment of amino acid substitutions and distinguish between soluble and membrane proteins. They also suffer from a number of further limitations, including data redundancy, lack of disease classification, incompatible information content, and ambiguous annotations (e.g. the same mutation being annotated as disease and benign).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We have developed a novel database, MutHTP, which contains information on 183 395 disease-associated and 17 827 neutral mutations in human transmembrane proteins. For each mutation site MutHTP provides a description of its location with respect to the membrane protein topology, structural environment (if available) and functional features. Comprehensive visualization, search, display and download options are available.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The database is publicly available at http:\/\/www.iitm.ac.in\/bioinfo\/MutHTP\/. The website is implemented using HTML, PHP and javascript and supports recent versions of all major browsers, such as Firefox, Chrome and Opera.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty054","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T18:56:35Z","timestamp":1517424995000},"page":"2325-2326","source":"Crossref","is-referenced-by-count":31,"title":["MutHTP: mutations in human transmembrane proteins"],"prefix":"10.1093","volume":"34","author":[{"given":"A","family":"Kulandaisamy","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Bhupat and Jyoti Mehta School of BioSciences, Indian Institute of Technology Madras, Chennai, Tamilnadu, India"}]},{"given":"S","family":"Binny Priya","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Bhupat and Jyoti Mehta School of BioSciences, Indian Institute of Technology Madras, Chennai, Tamilnadu, India"}]},{"given":"R","family":"Sakthivel","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Bhupat and Jyoti Mehta School of BioSciences, Indian Institute of Technology Madras, Chennai, Tamilnadu, India"}]},{"given":"Svetlana","family":"Tarnovskaya","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation"}]},{"given":"Ilya","family":"Bizin","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation"}]},{"given":"Peter","family":"H\u00f6nigschmid","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Technische Universit\u00e4t M\u00fcnchen, WissenschaftszentrumWeihenstephan, Freising, Germany"}]},{"given":"Dmitrij","family":"Frishman","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russian Federation"},{"name":"Department of Bioinformatics, Technische Universit\u00e4t M\u00fcnchen, WissenschaftszentrumWeihenstephan, Freising, Germany"}]},{"given":"M Michael","family":"Gromiha","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Bhupat and Jyoti Mehta School of BioSciences, Indian Institute of Technology Madras, Chennai, Tamilnadu, India"},{"name":"Advanced Computational Drug Discovery Unit (CADD), Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan"}]}],"member":"286","published-online":{"date-parts":[[2018,2,1]]},"reference":[{"key":"2023051604205102300_bty054-B1","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1016\/j.bbamem.2017.07.008","article-title":"Membrane proteins structures: a review on computational modeling tools","volume":"1859","author":"Almeida","year":"2017","journal-title":"Biochim. 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