{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:45:26Z","timestamp":1771267526199,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T00:00:00Z","timestamp":1517961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["275151 and 292307"],"award-info":[{"award-number":["275151 and 292307"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EU H2020 caLIBRAte","award":["686239"],"award-info":[{"award-number":["686239"]}]},{"name":"EU H2020 LIFEPATH","award":["633666"],"award-info":[{"award-number":["633666"]}]},{"name":"EU FP7 NANOSOLUTIONS","award":["FP7-309329"],"award-info":[{"award-number":["FP7-309329"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Detecting and interpreting responsive modules from gene expression data by using network-based approaches is a common but laborious task. It often requires the application of several computational methods implemented in different software packages, forcing biologists to compile complex analytical pipelines. Here we introduce INfORM (Inference of NetwOrk Response Modules), an R shiny application that enables non-expert users to detect, evaluate and select gene modules with high statistical and biological significance. INfORM is a comprehensive tool for the identification of biologically meaningful response modules from consensus gene networks inferred by using multiple algorithms. It is accessible through an intuitive graphical user interface allowing for a level of abstraction from the computational steps.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>INfORM is freely available for academic use at https:\/\/github.com\/Greco-Lab\/INfORM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty063","type":"journal-article","created":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T12:09:23Z","timestamp":1517918963000},"page":"2136-2138","source":"Crossref","is-referenced-by-count":42,"title":["INfORM: Inference of NetwOrk Response Modules"],"prefix":"10.1093","volume":"34","author":[{"given":"Veer Singh","family":"Marwah","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland"},{"name":"Institute of Biosciences and Medical Technologies (BioMediTech), Tampere, Finland"}]},{"given":"Pia Anneli Sofia","family":"Kinaret","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland"},{"name":"Institute of Biosciences and Medical Technologies (BioMediTech), Tampere, Finland"},{"name":"Institute of Biotechnology, University of Helsinki, Helsinki, Finland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3374-1492","authenticated-orcid":false,"given":"Angela","family":"Serra","sequence":"additional","affiliation":[{"name":"NeuRoNeLab, DISA-MIS, University of Salerno, Fisciano, Italy"}]},{"given":"Giovanni","family":"Scala","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland"},{"name":"Institute of Biosciences and Medical Technologies (BioMediTech), Tampere, Finland"}]},{"given":"Antti","family":"Lauerma","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland"}]},{"given":"Vittorio","family":"Fortino","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland"},{"name":"Institute of Biosciences and Medical Technologies (BioMediTech), Tampere, Finland"}]},{"given":"Dario","family":"Greco","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland"},{"name":"Institute of Biosciences and Medical Technologies (BioMediTech), Tampere, Finland"},{"name":"Institute of Biotechnology, University of Helsinki, Helsinki, Finland"}]}],"member":"286","published-online":{"date-parts":[[2018,2,7]]},"reference":[{"key":"2023012713375274200_bty063-B1","doi-asserted-by":"crossref","first-page":"P10008.","DOI":"10.1088\/1742-5468\/2008\/10\/P10008","article-title":"Fast unfolding of communities in large networks","volume":"2008","author":"Blondel","year":"2008","journal-title":"J. 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