{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T15:31:47Z","timestamp":1775230307165,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HG007358, R01EY024226"],"award-info":[{"award-number":["R01HG007358, R01EY024226"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>In this report, we introduce an R package KMgene for performing gene-based association tests for familial, multivariate or longitudinal traits using kernel machine (KM) regression under a generalized linear mixed model framework. Extensive simulations were performed to evaluate the validity of the approaches implemented in KMgene.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>http:\/\/cran.r-project.org\/web\/packages\/KMgene.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty066","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T20:11:40Z","timestamp":1518120700000},"page":"2144-2146","source":"Crossref","is-referenced-by-count":9,"title":["KMgene: a unified R package for gene-based association analysis for complex traits"],"prefix":"10.1093","volume":"34","author":[{"given":"Qi","family":"Yan","sequence":"first","affiliation":[{"name":"Division of Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA"}]},{"given":"Zhou","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA"},{"name":"Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"}]}],"member":"286","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"2023012713391930800_bty066-B1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/gepi.21791","article-title":"Sequence kernel association test for survival traits","volume":"38","author":"Chen","year":"2014","journal-title":"Genet. 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