{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:47:56Z","timestamp":1781023676030,"version":"3.54.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>How to comprehend the underlying mechanism behind the origin and evolution of genome composition such as GC content has been regarded as a long-standing crucial question, highlighting its biological significance and functional relevance. To varying extents, several systematically identified patterns of GC content variations are shown to be linked to a set of genomic features in the events of replication, transcription, translation and recombination, with strong contrasts between diverse phylogenetic or taxonomical groups. In this situation, we develop a repository\u2014GCevobase\u2014which houses compositional and size related data presented in various forms from 1118 genomes including 5 major clades of eukaryotic species such as vertebrates, invertebrates, plants, fungi and protists. It analyzes the cautiously selected sequences with clearly-defined bases and structures them under the taxonomical classification system (kingdom, phylum, class, order and family) at the genome and gene scales. It uses the diversified and intelligible graphs to show the statistical measurements of GC content in the sequence, at the three codon positions and at 4-fold degenerate sites and CDS length and their genome-wide correlations and display the evolutionary pathways of GC content by taking into account between-species orthologs and within-species paralogs for each annotated gene. In addition, a lot of internal and external links have been created, making it an effective communication between the data from individual genomes and the raw data are downloadable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>https:\/\/github.com\/NextGenBioinformatics\/GCevobase<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty068","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T20:13:13Z","timestamp":1517861593000},"page":"2129-2131","source":"Crossref","is-referenced-by-count":6,"title":["GCevobase: an evolution-based database for GC content in eukaryotic genomes"],"prefix":"10.1093","volume":"34","author":[{"given":"Dapeng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"2023012713393455500_bty068-B1","doi-asserted-by":"crossref","first-page":"e72.","DOI":"10.1093\/nar\/gks001","article-title":"Summarizing and correcting the GC content bias in high-throughput sequencing","volume":"40","author":"Benjamini","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2023012713393455500_bty068-B2","doi-asserted-by":"crossref","first-page":"538.","DOI":"10.1186\/1471-2164-10-538","article-title":"The isochore patterns of invertebrate genomes","volume":"10","author":"Cammarano","year":"2009","journal-title":"BMC Genomics"},{"key":"2023012713393455500_bty068-B3","doi-asserted-by":"crossref","first-page":"146.","DOI":"10.1186\/1471-2164-10-146","article-title":"The evolution of isochore patterns in vertebrate genomes","volume":"10","author":"Costantini","year":"2009","journal-title":"BMC Genomics"},{"key":"2023012713393455500_bty068-B4","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/35080577","article-title":"The evolution of isochores","volume":"2","author":"Eyre-Walker","year":"2001","journal-title":"Nat. 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