{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:48:01Z","timestamp":1780638481750,"version":"3.54.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"Eberly College of Sciences and Institute of CyberScience"},{"DOI":"10.13039\/100008321","name":"Pennsylvania State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["UL1TR000127"],"award-info":[{"award-number":["UL1TR000127"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tobacco Settlement and CURE"},{"DOI":"10.13039\/100004897","name":"PA Department of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004897","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>With increased generation of high-resolution sequence-based \u2018Omics\u2019 data, detecting statistically significant effects at different genomic locations and scales has become key to addressing several scientific questions. IWTomics is an R\/Bioconductor package (integrated in Galaxy) that, exploiting sophisticated Functional Data Analysis techniques (i.e. statistical techniques that deal with the analysis of curves), allows users to pre-process, visualize and test these data at multiple locations and scales. The package provides a friendly, flexible and complete workflow that can be employed in many genomic and epigenomic applications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>IWTomics is freely available at the Bioconductor website (http:\/\/bioconductor.org\/packages\/IWTomics) and on the main Galaxy instance (https:\/\/usegalaxy.org\/).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty090","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T20:13:52Z","timestamp":1519157632000},"page":"2289-2291","source":"Crossref","is-referenced-by-count":12,"title":["IWTomics: testing high-resolution sequence-based \u2018Omics\u2019 data at multiple locations and scales"],"prefix":"10.1093","volume":"34","author":[{"given":"Marzia A","family":"Cremona","sequence":"first","affiliation":[{"name":"Department of Statistics, The Pennsylvania State University, University Park, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Pini","sequence":"additional","affiliation":[{"name":"MOX - Department of Mathematics, Politecnico di Milano, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Cumbo","sequence":"additional","affiliation":[{"name":"Department of Engineering, Third University of Rome, Italy"},{"name":"Institute for Systems Analysis and Computer Science \u2018Antonio Ruberti\u2019, National Research Council of Italy, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kateryna D","family":"Makova","sequence":"additional","affiliation":[{"name":"Center for Medical Genomics, The Huck Institutes of the Life Sciences"},{"name":"Department of Biology, The Pennsylvania State University, University Park, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Chiaromonte","sequence":"additional","affiliation":[{"name":"Department of Statistics, The Pennsylvania State University, University Park, USA"},{"name":"Center for Medical Genomics, The Huck Institutes of the Life Sciences"},{"name":"Sant\u2019Anna School of Advanced Studies, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Vantini","sequence":"additional","affiliation":[{"name":"MOX - Department of Mathematics, Politecnico di Milano, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"2023051604101053300_bty090-B1","doi-asserted-by":"crossref","first-page":"W3.","DOI":"10.1093\/nar\/gkw343","article-title":"The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update","volume":"44","author":"Afgan","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2023051604101053300_bty090-B2","doi-asserted-by":"crossref","first-page":"e1004956","DOI":"10.1371\/journal.pcbi.1004956","article-title":"Integration and fixation preferences of human and mouse endogenous retroviruses uncovered with functional data analysis","volume":"12","author":"Campos-S\u00e1nchez","year":"2016","journal-title":"PLoS Comput. 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