{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:45:07Z","timestamp":1740185107650,"version":"3.37.3"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"United States \u2013 Israel Binational Science Foundation","award":["2013071"],"award-info":[{"award-number":["2013071"]}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Edmond J. Safra Center for Bioinformatics"},{"DOI":"10.13039\/501100004375","name":"Tel Aviv University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005155","name":"Azrieli Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005155","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Azrieli Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>The COP9 signalosome is a highly conserved multi-protein complex consisting of eight subunits, which influences key developmental pathways through its regulation of protein stability and transcription. In Arabidopsis thaliana, mutations in the COP9 signalosome exhibit a number of diverse pleiotropic phenotypes. Total or partial loss of COP9 signalosome function in Arabidopsis leads to misregulation of a number of genes involved in DNA methylation, suggesting that part of the pleiotropic phenotype is due to global effects on DNA methylation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We determined and analyzed the methylomes and transcriptomes of both partial- and total-loss-of-function Arabidopsis mutants of the COP9 signalosome. Our results support the hypothesis that the COP9 signalosome has a global genome-wide effect on methylation and that this effect is at least partially encoded in the DNA. Our analyses suggest that COP9 signalosome-dependent methylation is related to gene expression regulation in various ways. Differentially methylated regions tend to be closer in the 3D conformation of the genome to differentially expressed genes. These results suggest that the COP9 signalosome has a more comprehensive effect on gene expression than thought before, and this is partially related to regulation of methylation. The high level of COP9 signalosome conservation among eukaryotes may also suggest that COP9 signalosome regulates methylation not only in plants but also in other eukaryotes, including humans.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty1053","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T14:17:15Z","timestamp":1545401835000},"page":"2718-2723","source":"Crossref","is-referenced-by-count":7,"title":["The COP9 signalosome influences the epigenetic landscape of <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-7068","authenticated-orcid":false,"given":"Tamir","family":"Tuller","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering"},{"name":"Sagol School of Neuroscience"}]},{"given":"Alon","family":"Diament","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering"}]},{"given":"Avital","family":"Yahalom","sequence":"additional","affiliation":[{"name":"School of Plant Sciences and Food Security, Tel Aviv University, Tel Aviv, Israel"}]},{"given":"Assaf","family":"Zemach","sequence":"additional","affiliation":[{"name":"School of Plant Sciences and Food Security, Tel Aviv University, Tel Aviv, Israel"}]},{"given":"Shimshi","family":"Atar","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering"}]},{"given":"Daniel A","family":"Chamovitz","sequence":"additional","affiliation":[{"name":"School of Plant Sciences and Food Security, Tel Aviv University, Tel Aviv, Israel"}]}],"member":"286","published-online":{"date-parts":[[2018,12,28]]},"reference":[{"key":"2023062708550158300_bty1053-B1","first-page":"14.","article-title":"The RAR1 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