{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:19:18Z","timestamp":1762899558724,"version":"3.37.3"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"Ministry of Human Capacities of Hungary","award":["VEKOP-2.3.2-16-2017-00014","NKFI-126472"],"award-info":[{"award-number":["VEKOP-2.3.2-16-2017-00014","NKFI-126472"]}]},{"DOI":"10.13039\/100017864","name":"Ministry for National Economy","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017864","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Research, Development and Innovation Office of Hungary"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Artificial intelligence tools are gaining more and more ground each year in bioinformatics. Learning algorithms can be taught for specific tasks by using the existing enormous biological databases, and the resulting models can be used for the high-quality classification of novel, un-categorized data in numerous areas, including biological sequence analysis. Here, we introduce SECLAF, a webserver that uses deep neural networks for hierarchical biological sequence classification. By applying SECLAF for residue-sequences, we have reported [Methods (2018), https:\/\/doi.org\/10.1016\/j.ymeth.2017.06.034] the most accurate multi-label protein classifier to date (UniProt\u2014into 698 classes\u2014AUC 99.99%; Gene Ontology\u2014into 983 classes\u2014AUC 99.45%). Our framework SECLAF can be applied for other sequence classification tasks, as we describe in the present contribution.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The program SECLAF is implemented in Python, and is available for download, with example datasets at the website https:\/\/pitgroup.org\/seclaf\/. For Gene Ontology and UniProt based classifications a webserver is also available at the address above.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty116","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T20:18:15Z","timestamp":1519676295000},"page":"2487-2489","source":"Crossref","is-referenced-by-count":21,"title":["SECLAF: a webserver and deep neural network design tool for hierarchical biological sequence classification"],"prefix":"10.1093","volume":"34","author":[{"given":"Bal\u00e1zs","family":"Szalkai","sequence":"first","affiliation":[{"name":"PIT Bioinformatics Group, Institute of Mathematics, E\u00f6tv\u00f6s University, H-1117 Budapest, Hungary"}]},{"given":"Vince","family":"Grolmusz","sequence":"additional","affiliation":[{"name":"PIT Bioinformatics Group, Institute of Mathematics, E\u00f6tv\u00f6s University, H-1117 Budapest, Hungary"},{"name":"Uratim Ltd, H-1118 Budapest, Hungary"}]}],"member":"286","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"first-page":"1","year":"2016","author":"Abadi","key":"2023012713015186700_bty116-B1"},{"key":"2023012713015186700_bty116-B2","first-page":"265","volume-title":"Proceedings of the 12th USENIX Symposium on Operating Systems Design and Implementation (OSDI)","author":"Abadi","year":"2016"},{"key":"2023012713015186700_bty116-B3","doi-asserted-by":"crossref","first-page":"D1049","DOI":"10.1093\/nar\/gku1179","article-title":"Gene ontology consortium: going forward","volume":"43","author":"Gene Ontology Consortium","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2023012713015186700_bty116-B4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF02478259","article-title":"A logical calculus of the ideas immanent in nervous activity","volume":"5","author":"McCulloch","year":"1943","journal-title":"Bull. Math. 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