{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:42:54Z","timestamp":1761964974723,"version":"3.37.3"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 CA197745-03"],"award-info":[{"award-number":["R35 CA197745-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Outstanding Investigator Award","award":["U54 CA209997"],"award-info":[{"award-number":["U54 CA209997"]}]},{"name":"Centers for Cancer Systems Therapeutics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>In a scenario where populations A, B1 and B2 (subpopulations of B) exist, pronounced differences between A and B may mask subtle differences between B1 and B2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Here we present iterClust, an iterative clustering framework, which can separate more pronounced differences (e.g. A and B) in starting iterations, followed by relatively subtle differences (e.g. B1 and B2), providing a comprehensive clustering trajectory.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>iterClust is implemented as a Bioconductor R package.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty176","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T20:12:36Z","timestamp":1521663156000},"page":"2865-2866","source":"Crossref","is-referenced-by-count":9,"title":["iterClust: a statistical framework for iterative clustering analysis"],"prefix":"10.1093","volume":"34","author":[{"given":"Hongxu","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Systems Biology, Columbia University, New York, NY, USA"},{"name":"Department of Biological Sciences, Columbia University, New York, NY, USA"}]},{"given":"Wanxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Stanford University, Stanford, CA, USA"}]},{"given":"Andrea","family":"Califano","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, Columbia University, New York, NY, USA"},{"name":"Herbert Irving Comprehensive Cancer Center, J.P. Sulzberger Columbia Genome Center, Department of Biomedical Informatics, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA"}]}],"member":"286","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"2023012712592467800_bty176-B1","first-page":"226","article-title":"A density-based algorithm for discovering clusters in large spatial databases with noise","volume":"96","author":"Ester","year":"1996","journal-title":"KDD"},{"volume-title":"Finding Groups in Data: An Introduction to Cluster Analysis","year":"2009","author":"Kaufman","key":"2023012712592467800_bty176-B2"},{"key":"2023012712592467800_bty176-B3","first-page":"2579","article-title":"Visualizing data using t-SNE","volume":"9","author":"Maaten","year":"2008","journal-title":"J. Mach. Learn. 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Math"},{"key":"2023012712592467800_bty176-B8","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1093\/bioinformatics\/btm344","article-title":"A review of feature selection techniques in bioinformatics","volume":"23","author":"Saeys","year":"2007","journal-title":"Bioinformatics"},{"key":"2023012712592467800_bty176-B9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.3881","article-title":"Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing","volume":"18","author":"Usoskin","year":"2015","journal-title":"Nat. Neurosci"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/16\/2865\/48917924\/bioinformatics_34_16_2865.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/16\/2865\/48917924\/bioinformatics_34_16_2865.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T13:48:15Z","timestamp":1674827295000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/34\/16\/2865\/4951451"}},"subtitle":[],"editor":[{"given":"Jonathan","family":"Wren","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2018,3,22]]},"references-count":8,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2018,8,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bty176","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"type":"print","value":"1367-4803"},{"type":"electronic","value":"1367-4811"}],"subject":[],"published-other":{"date-parts":[[2018,8,15]]},"published":{"date-parts":[[2018,3,22]]}}}