{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:25:07Z","timestamp":1768454707924,"version":"3.49.0"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Korea Health Technology R&D Project"},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"KHIDI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["HC15C1302"],"award-info":[{"award-number":["HC15C1302"]}]},{"name":"Bio-Synergy Research","award":["NRF-2017M3A9C4065964"],"award-info":[{"award-number":["NRF-2017M3A9C4065964"]}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Despite the need for separate tools to analyze family-based data, there are only a handful of tools optimized for family-based big data compared to the number of tools available for analyzing population-based data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>ONETOOL implements the properties of well-known existing family data analysis tools and recently developed methods in a computationally efficient manner, and so is suitable for analyzing the vast amount of variant data available from sequencing family members, providing a rich choice of analysis methods for big data on families.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>ONETOOL is freely available from http:\/\/healthstat.snu.ac.kr\/software\/onetool\/.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty180","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T19:12:05Z","timestamp":1522091525000},"page":"2851-2853","source":"Crossref","is-referenced-by-count":34,"title":["ONETOOL for the analysis of family-based big data"],"prefix":"10.1093","volume":"34","author":[{"given":"Yeunjoo E","family":"Song","sequence":"first","affiliation":[{"name":"Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA"}]},{"given":"Sungyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul, Korea"}]},{"given":"Kyungtaek","family":"Park","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul, Korea"}]},{"given":"Robert C","family":"Elston","sequence":"additional","affiliation":[{"name":"Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA"}]},{"given":"Hyeon-Jong","family":"Yang","sequence":"additional","affiliation":[{"name":"SCH Biomedical Informatics Research Unit, Soonchunhyang University Hospital, Seoul, Korea"},{"name":"Department of Pediatrics, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea"}]},{"given":"Sungho","family":"Won","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program of Bioinformatics, Seoul National University, Seoul, Korea"},{"name":"Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea"},{"name":"Institute of Health and Environment, Seoul National University, Seoul, Korea"}]}],"member":"286","published-online":{"date-parts":[[2018,3,27]]},"reference":[{"key":"2023012712584029200_bty180-B1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng786","article-title":"Merlin-rapid analysis of dense genetic maps using sparse gene flow tree","volume":"30","author":"Abecasis","year":"2002","journal-title":"Nat. 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Genet"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/16\/2851\/48917687\/bioinformatics_34_16_2851.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/16\/2851\/48917687\/bioinformatics_34_16_2851.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T13:46:59Z","timestamp":1674827219000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/34\/16\/2851\/4955191"}},"subtitle":[],"editor":[{"given":"Oliver","family":"Stegle","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2018,3,27]]},"references-count":5,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2018,8,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bty180","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,8,15]]},"published":{"date-parts":[[2018,3,27]]}}}