{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:39:08Z","timestamp":1774975148772,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"crossref","award":["106-2622-B-002-008-"],"award-info":[{"award-number":["106-2622-B-002-008-"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"crossref","award":["106-2911-I-002-533"],"award-info":[{"award-number":["106-2911-I-002-533"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"crossref","award":["106-2321-B-002-041-"],"award-info":[{"award-number":["106-2321-B-002-041-"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"crossref","award":["105-3011-F-002-010-"],"award-info":[{"award-number":["105-3011-F-002-010-"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["NTU-CDP-106R7820"],"award-info":[{"award-number":["NTU-CDP-106R7820"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["NTU-ERP-106R880803"],"award-info":[{"award-number":["NTU-ERP-106R880803"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["NTU-107L7820"],"award-info":[{"award-number":["NTU-107L7820"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Resources of the Laboratory of Computational Molecular Design and Metabolomics"},{"name":"Department of Computer Science and Information Engineering of National Taiwan University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Lipids are divided into fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, sterols, prenol lipids and polyketides. Fatty acyls and glycerolipids are commonly used as energy storage, whereas glycerophospholipids, sphingolipids, sterols and saccharolipids are common used as components of cell membranes. Lipids in fatty acyls, glycerophospholipids, sphingolipids and sterols classes play important roles in signaling. Although more than 36 million lipids can be identified or computationally generated, no single lipid database provides comprehensive information on lipids. Furthermore, the complex systematic or common names of lipids make the discovery of related information challenging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Here, we present LipidPedia, a comprehensive lipid knowledgebase. The content of this database is derived from integrating annotation data with full-text mining of 3923 lipids and more than 400 000 annotations of associated diseases, pathways, functions and locations that are essential for interpreting lipid functions and mechanisms from over 1 400 000 scientific publications. Each lipid in LipidPedia also has its own entry containing a text summary curated from the most frequently cited diseases, pathways, genes, locations, functions, lipids and experimental models in the biomedical literature. LipidPedia aims to provide an overall synopsis of lipids to summarize lipid annotations and provide a detailed listing of references for understanding complex lipid functions and mechanisms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>LipidPedia is available at http:\/\/lipidpedia.cmdm.tw.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty213","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T07:55:06Z","timestamp":1523260506000},"page":"2982-2987","source":"Crossref","is-referenced-by-count":41,"title":["LipidPedia: a comprehensive lipid knowledgebase"],"prefix":"10.1093","volume":"34","author":[{"given":"Tien-Chueh","family":"Kuo","sequence":"first","affiliation":[{"name":"Graduate Institute of Biomedical Engineering and Bioinformatics, National Taiwan University, Taipei, Taiwan"},{"name":"The Metabolomics Core Laboratory, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan"}]},{"given":"Yufeng Jane","family":"Tseng","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Engineering and Bioinformatics, National Taiwan University, Taipei, Taiwan"},{"name":"The Metabolomics Core Laboratory, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan"},{"name":"Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan"},{"name":"School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan"}]}],"member":"286","published-online":{"date-parts":[[2018,4,10]]},"reference":[{"key":"2023061313382409600_bty213-B1","author":"Baldridge","year":"2005"},{"key":"2023061313382409600_bty213-B2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/2162-3619-3-24","article-title":"Targeting cholesterol synthesis increases chemoimmuno-sensitivity in chronic lymphocytic leukemia cells","volume":"3","author":"Benakanakere","year":"2014","journal-title":"Exp. 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