{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:44:35Z","timestamp":1740185075946,"version":"3.37.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T00:00:00Z","timestamp":1524182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Department of Mathematics and Statistics"},{"name":"The Finnish Cultural Foundation"},{"DOI":"10.13039\/501100005424","name":"Varsinais-Suomi Regional Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005424","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA200417"],"award-info":[{"award-number":["R01CA200417"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>The collective and co-ordinated synaptic activity of large neuronal populations is relevant to neuronal development as well as a range of neurological diseases. Quantification of synaptically-mediated neuronal signalling permits further downstream analysis as well as potential application in target validation and in vitro screening assays. Our aim is to develop a phenotypic quantification for neuronal activity imaging data of large populations of neurons, in particular relating to the spatial component of the activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We extend the use of Markov random field (MRF) models to achieve this aim. In particular, we consider Bayesian posterior densities of model parameters in Gaussian MRFs to directly model changes in calcium fluorescence intensity rather than using spike trains. The basis of our model is defining neuron \u2018neighbours\u2019 by the relative spatial positions of the neuronal somata as obtained from the image data whereas previously this has been limited to defining an artificial square grid across the field of view and spike binning. We demonstrate that our spatial phenotypic quantification is applicable for both in vitro and in vivo data consisting of thousands of neurons over hundreds of time points. We show how our approach provides insight beyond that attained by conventional spike counting and discuss how it could be used to facilitate screening assays for modifiers of disease-associated defects of communication between cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>We supply the MATLAB code and data to obtain all of the results in the paper.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty322","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T19:10:53Z","timestamp":1524165053000},"page":"3196-3204","source":"Crossref","is-referenced-by-count":0,"title":["Spatial quantification of the synaptic activity phenotype across large populations of neurons with Markov random fields"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3957-1735","authenticated-orcid":false,"given":"Sean","family":"Robinson","sequence":"first","affiliation":[{"name":"Department of Mathematics and Statistics, University of Turku, Turku, Finland"},{"name":"Universit\u00e9 Grenoble Alpes, CEA, INSERM, Biology of Cancer and Infection UMR S 1036, Grenoble, France"}]},{"given":"Michael J","family":"Courtney","sequence":"additional","affiliation":[{"name":"Neuronal Signalling Lab, Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland"},{"name":"Screening Unit, Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, and Institute of Biomedicine, University of Turku, Turku, Finland"},{"name":"Turku Brain and Mind Center, University of Turku and \u00c5bo Akademi University, Turku, Finland"}]}],"member":"286","published-online":{"date-parts":[[2018,4,20]]},"reference":[{"key":"2023012710302851100_bty322-B1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00422-003-0416-8","article-title":"Parameter estimation in a model for multidimensional recording of neuronal data: a Gibbsian approximation approach","volume":"89","author":"Abdallahi","year":"2003","journal-title":"Biol. 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