{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:32:43Z","timestamp":1761539563397,"version":"3.37.3"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T00:00:00Z","timestamp":1524528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","award":["FDN-154287"],"award-info":[{"award-number":["FDN-154287"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Here, we present MetaBridge, a tool that collates protein interactors (curated metabolite-enzyme interactions) that influence the levels of specific metabolites including both biosynthetic and degradative enzymes. This enables network-based integrative analysis of metabolomics data with other omics data types. MetaBridge is designed to complement a systems-biology approach to analysis, pairing well with network analysis tools such as NetworkAnalyst.ca, but can be used in any bioinformatics workflow.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>MetaBridge has been implemented as a web tool at https:\/\/www.metabridge.org, and the source code is available at https:\/\/github.com\/samhinshaw\/metabridge_shiny (GNU GPLv3).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty331","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T06:41:15Z","timestamp":1524465675000},"page":"3225-3227","source":"Crossref","is-referenced-by-count":19,"title":["MetaBridge: enabling network-based integrative analysis via direct protein interactors of metabolites"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3322-3492","authenticated-orcid":false,"given":"Samuel J","family":"Hinshaw","sequence":"first","affiliation":[{"name":"Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada"}]},{"given":"Amy","family":"H Y Lee","sequence":"additional","affiliation":[{"name":"Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada"}]},{"given":"Erin E","family":"Gill","sequence":"additional","affiliation":[{"name":"Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada"}]},{"given":"Robert","family":"E W Hancock","sequence":"additional","affiliation":[{"name":"Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, BC, Canada"}]}],"member":"286","published-online":{"date-parts":[[2018,4,24]]},"reference":[{"key":"2023012704184811700_bty331-B1","doi-asserted-by":"crossref","first-page":"D471","DOI":"10.1093\/nar\/gkv1164","article-title":"The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway\/genome databases","volume":"44","author":"Caspi","year":"2016","journal-title":"Nucleic Acids Res"},{"year":"2017","author":"Chang","key":"2023012704184811700_bty331-B2"},{"key":"2023012704184811700_bty331-B3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrg.2016.49","article-title":"Coming of age: ten years of next-generation sequencing technologies","volume":"17","author":"Goodwin","year":"2016","journal-title":"Nat. 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