{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:44:52Z","timestamp":1740185092617,"version":"3.37.3"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T00:00:00Z","timestamp":1529452800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ELIXIR"},{"name":"ELIXIR CZ"},{"DOI":"10.13039\/501100003335","name":"MEYS","doi-asserted-by":"publisher","award":["LM2015047"],"award-info":[{"award-number":["LM2015047"]}],"id":[{"id":"10.13039\/501100003335","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institute of Organic Chemistry and Biochemistry of the CAS","award":["61388963"],"award-info":[{"award-number":["61388963"]}]},{"name":"RDF"},{"DOI":"10.13039\/100013060","name":"EMBL","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Amino acid residues showing above background levels of conservation are often indicative of functionally significant regions within a protein. Understanding how the sequence conservation profile relates in space requires projection onto a protein structure, a potentially time-consuming process. 3DPatch is a web application that streamlines this task by automatically generating multiple sequence alignments (where appropriate) and finding structural homologs, presenting the user with a choice of structures matching their query, annotated with residue conservation scores in a matter of seconds.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>3DPatch is written in JavaScript and is freely available at http:\/\/www.skylign.org\/3DPatch\/. Mozilla Firefox, Google Chrome, and Safari web browsers are supported. Source code is available under MIT license at https:\/\/github.com\/davidjakubec\/3DPatch.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty464","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T11:08:45Z","timestamp":1528456125000},"page":"332-334","source":"Crossref","is-referenced-by-count":2,"title":["3DPatch: fast 3D structure visualization with residue conservation"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4288-0344","authenticated-orcid":false,"given":"David","family":"Jakubec","sequence":"first","affiliation":[{"name":"Department of Bioinformatics, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague 6, 166 10, Czech Republic"},{"name":"Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague 2, 128 43, Czech Republic"}]},{"given":"Ji\u0159\u00ed","family":"Vondr\u00e1\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague 6, 166 10, Czech Republic"}]},{"given":"Robert D","family":"Finn","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK"}]}],"member":"286","published-online":{"date-parts":[[2018,6,10]]},"reference":[{"key":"2023013107232029400_bty464-B1","doi-asserted-by":"crossref","first-page":"W344","DOI":"10.1093\/nar\/gkw408","article-title":"ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules","volume":"44","author":"Ashkenazy","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2023013107232029400_bty464-B2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ijch.201200096","article-title":"ConSurf: using evolutionary data to raise testable hypotheses about protein function","volume":"53","author":"Celniker","year":"2013","journal-title":"Isr. 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