{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:10:38Z","timestamp":1770333038453,"version":"3.49.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"publisher","award":["217066"],"award-info":[{"award-number":["217066"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Genome Canada\/Ontario Genomics","award":["9408"],"award-info":[{"award-number":["9408"]}]},{"name":"RapidAIM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>The human gut microbiota, a complex, dynamic and biodiverse community, has been increasingly shown to influence many aspects of health and disease. Metaproteomic analysis has proven to be a powerful approach to study the functionality of the microbiota. However, the processing and analyses of metaproteomic mass spectrometry data remains a daunting task in metaproteomics data analysis. We developed iMetaLab, a web based platform to provide a user-friendly and comprehensive data analysis pipeline with a focus on lowering the technical barrier for metaproteomics data analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>iMetaLab is freely available through at http:\/\/imetalab.ca.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/bty466","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T19:14:31Z","timestamp":1528744471000},"page":"3954-3956","source":"Crossref","is-referenced-by-count":47,"title":["iMetaLab 1.0: a web platform for metaproteomics data analysis"],"prefix":"10.1093","volume":"34","author":[{"given":"Bo","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}]},{"given":"Zhibin","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}]},{"given":"Kai","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}]},{"given":"Leyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}]},{"given":"Janice","family":"Mayne","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}]},{"given":"Daniel","family":"Figeys","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Molecular Architecture of Life Program, Canadian Institute for Advanced Research, Toronto, Ontario, Canada"},{"name":"Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada"}]}],"member":"286","published-online":{"date-parts":[[2018,6,15]]},"reference":[{"key":"2023012712363628900_bty466-B1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s40168-017-0375-2","article-title":"MetaLab: an automated pipeline for metaproteomic data analysis","volume":"5","author":"Cheng","year":"2017","journal-title":"Microbiome"},{"key":"2023012712363628900_bty466-B2","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The impact of the gut microbiota on human health: an integrative view","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"key":"2023012712363628900_bty466-B3","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"2023012712363628900_bty466-B4","doi-asserted-by":"crossref","first-page":"e1004957","DOI":"10.1371\/journal.pcbi.1004957","article-title":"MEGAN community edition\u2014interactive exploration and analysis of large-scale microbiome sequencing data","volume":"12","author":"Huson","year":"2016","journal-title":"PLoS Comput. Biol."},{"key":"2023012712363628900_bty466-B5","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/pmic.201200352","article-title":"A two-step database search method improves sensitivity in peptide sequence matches for metaproteomics and proteogenomics studies","volume":"13","author":"Jagtap","year":"2013","journal-title":"Proteomics"},{"key":"2023012712363628900_bty466-B6","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nbt.2942","article-title":"An integrated catalog of reference genes in the human gut microbiome","volume":"32","author":"Li","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"2023012712363628900_bty466-B7","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1021\/acs.jproteome.6b00239","article-title":"An alignment-free \u201cmetapeptide\u201d strategy for metaproteomic characterization of microbiome samples using shotgun metagenomic sequencing","volume":"15","author":"May","year":"2016","journal-title":"J. Proteome Res."},{"key":"2023012712363628900_bty466-B8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/ismej.2016.132","article-title":"Critical decisions in metaproteomics: achieving high confidence protein annotations in a sea of unknowns","volume":"11","author":"Timmins-Schiffman","year":"2017","journal-title":"ISME J."},{"key":"2023012712363628900_bty466-B9","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/nbt.3353","article-title":"A catalog of the mouse gut metagenome","volume":"33","author":"Xiao","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"2023012712363628900_bty466-B10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40168-016-0176-z","article-title":"MetaPro-IQ: a universal metaproteomic approach to studying human and mouse gut microbiota","volume":"4","author":"Zhang","year":"2016","journal-title":"Microbiome"},{"key":"2023012712363628900_bty466-B11","doi-asserted-by":"crossref","first-page":"9407","DOI":"10.1021\/acs.analchem.7b02224","article-title":"Deep metaproteomics approach for the study of human microbiomes","volume":"89","author":"Zhang","year":"2017","journal-title":"Anal. Chem."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/22\/3954\/48921010\/bioinformatics_34_22_3954.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/34\/22\/3954\/48921010\/bioinformatics_34_22_3954.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T13:25:55Z","timestamp":1674825955000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/34\/22\/3954\/5038462"}},"subtitle":[],"editor":[{"given":"Jonathan","family":"Wruen","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2018,6,15]]},"references-count":11,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2018,11,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bty466","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,11,15]]},"published":{"date-parts":[[2018,6,15]]}}}